Bowel cleansing chemical composition and associated use therefore

a technology of bowel cleansing and chemical composition, which is applied in the direction of pharmaceutical delivery mechanism, organic active ingredient, dispersed delivery, etc., can solve the problems of insufficient upper endoscopy examination, insufficient visualization and careful examination of the bowel surface, and insufficient preparation of the bowel

Active Publication Date: 2022-04-12
ENDOLOGIC LLC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Despite best efforts for cleansing the bowel prior to doing a colonoscopy, there is always some residual stool and secretions in the bowel, which pose a hindrance in visualization and careful examination of the surface of the bowel.
Suboptimal bowel preparations add a significant cost to our healthcare resources.
Due to underlying motility problems, some patients do not have a clean stomach thereby making the exam suboptimal.
Some patients have copious amounts of foam also making the upper endoscopy exam inadequate.
Although conventional methods employ water for cleansing during a colonoscopy or EGD, it is not ideal.
Stool present during a colonoscopy is often adherent and sticky.
Using water in these circumstances is ineffective and leads to more foaming that further obstructs the view and making the exam worse.
Similarly, during an EGD, food residue and blood cannot be cleaned adequately with water.

Method used

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  • Bowel cleansing chemical composition and associated use therefore

Examples

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Comparison scheme
Effect test

example 1

[0061]In a non-limiting exemplary embodiment, the GRAS list bowel cleansing chemical composition 10 may be employed in the following scenario. A patient with an average risk for colon cancer comes for a colonoscopy for colon cancer screening. An endoscopist performs the colonoscopy. The left and middle segments (rectum, sigmoid bowel, descending bowel and transverse bowel) of the bowel is adequately cleaned with good visualization of the bowel. However, the right segment (ascending bowel and cecum) cannot be visualized due to thick dark adherent stool lining the walls of the bowel. The endoscopist washes the wall with water using an irrigation pump. Some of the sticky stool comes off the wall but now the lumen of the bowel is filled with a foam as a result of the washing. The water-stool mixture can be suctioned off, but the foam persists. The endoscopist uses the GRAS list bowel cleansing chemical composition 10 to wash the bowel with the irrigation pump. The GRAS list bowel cleans...

example 2

[0062]In a non-limiting exemplary embodiment, the GRAS list bowel cleansing chemical composition 10 may be employed in the following scenario. A patient with a history of bowel polyps comes for a colonoscopy. The entire bowel is clean with no stool on the wall of the bowel. However, in the cecum there is a dark liquid (bile). The endoscopist irrigates with water to suction the liquid. The entire cecum fills up with yellow foam and makes the visualization of the cecum worse. The endoscopist uses the GRAS list bowel cleansing chemical composition 10 to irrigate and suction. The cecum is now clearly visible, and the foam has dissipated. The endoscopist notes a broad-based polyp in the cecum. The polyp is sent for analysis. The pathology report states that it is an adenomatous polyp with early bowel cancer. Using water to clean the bowel in this patient would have resulted in a missed polyp leading to bowel cancer in the future. The use of the GRAS list bowel cleansing chemical composit...

example 3

[0063]In a non-limiting exemplary embodiment, the GRAS list bowel cleansing chemical composition 10 may be employed in the following scenario. A patient is admitted to the hospital with abdominal pain, anemia and black tarry stools. The gastroenterologist suspects a bleeding ulcer. An upper endoscopy is performed. The stomach shows “coffee ground” like material indicating oxidized blood. The stomach does not show any ulcers. The duodenum is approached but there is a bile and blood mixture. The endoscopist uses water to clean and suction, however the situation gets worse due to the foam, now the wall of the duodenum is not visible where the ulcer is suspected and is bleeding. The endoscopist uses the GRAS list bowel cleansing chemical composition 10 to clean the area, the foam disappears and a duodenal ulcer with a visible blood vessel is seen. Since the area is now clearly visible, the endoscopist treats the ulcer with cautery and injection and stops it from bleeding again. The pati...

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Abstract

A GRAS list chemical composition (containing only GRAS list approved ingredients) including a water-based bowel cleansing solution (either in concentrate form or diluted form) to clean a gastrointestinal (GI) tract before and / or during performance of an endoscopy procedure such as a colonoscopy, enteroscopy, upper gastrointestinal endoscopy, and small bowel capsule endoscopy, for example. The GRAS list bowel cleansing chemical composition includes at least one of a chemical composition as a liquid, tablet or powder concentrate that can be added to sterile water or other solution by the end-user to make the chemical composition solution; and a pre-mixed chemical composition solution diluted in up to 1000 ml of sterile water.

Description

CROSS REFERENCE TO RELATED APPLICATIONS[0001]This is a non-provisional patent application that claims the benefit of U.S. provisional patent application No. 62 / 782,485 filed Dec. 20, 2018, which is incorporated by reference herein in its entirety.STATEMENT REGARDING FEDERALLY SPONSORED RESEARCH OR DEVELOPMENT[0002]Not Applicable.REFERENCE TO A MICROFICHE APPENDIX[0003]Not Applicable.BACKGROUNDTechnical Field[0004]Exemplary embodiment(s) of the present disclosure relate to bowel cleansing chemical compositions and, more particularly, to a GRAS list chemical composition (containing only GRAS list approved ingredients) including a water-based bowel cleansing solution (either in concentrate form or diluted form) to clean a gastrointestinal (GI) tract before and / or during performance of an endoscopy procedure such as a colonoscopy, upper gastrointestinal endoscopy, and small bowel capsule endoscopy, for example.Prior Art[0005]Approximately, 30 million colonoscopy, 10 million upper gastro...

Claims

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Application Information

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Patent Type & Authority Patents(United States)
IPC IPC(8): A61K31/765A61K31/255A61K9/08A61K9/14A61K9/20A61K9/00
CPCA61K31/765A61K9/08A61K9/14A61K9/20A61K31/255A61K9/0053A61K9/0095A61K47/12A61K47/10
Inventor BRELVI, ZAMIRDUTTA, KAMAL
Owner ENDOLOGIC LLC
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