Temperature sensitive state-changing hydrogel composition and method for preparation

a technology of hydrogel and temperature sensitive state, applied in the direction of instruments, aerosol delivery, biocide, etc., can solve the problems of affecting the speed and quantity of drug delivery, the relative long time it takes for the medicine to penetrate into the skin, and the limitations of hydrogel in the form of gel

Inactive Publication Date: 2005-02-17
UGENIC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

When hydrogel is in the gel state, it takes relatively long time for the medicine to penetrate into skin, and the drug could only be delivered to the limited area where the hydrogel directly contacts the skin.
However, even though hydrogel is used, there are limitations w...

Method used

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  • Temperature sensitive state-changing hydrogel composition and method for preparation
  • Temperature sensitive state-changing hydrogel composition and method for preparation
  • Temperature sensitive state-changing hydrogel composition and method for preparation

Examples

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example 1

[0052] Mix glycerine 170 g, Carrageenan 6 g and Locastgum 20 g at room temperature and stir in a 3 liter heatable container. Add to the mixture solution glycerine 30 g, metilparaben 0.8 g, propileparaben 0.3 g. Add 740 g of deionized water and heat the solution to 85° C. This will be the gel solution.

[0053] While maintaining the temperature at 85° C., add sequentially aloe extraction 20 g, collagen 5 g, imidazolidinylurea 2 g, twin80 1.5 g, and chitosan 3.7 g to the gel solution. This is the hydrogel composition. FIG. 1 shows the viscosity of the above hydrogel composition measured at various temperatures. As it is shown in FIG. 1, the hydrogel composition decreases its viscosity when the temperature increases and transforms to liquid state.

[0054] Hydrogel sheet can be produced by adding a rayon textile as a wick to this hydrogel composition at the temperature of 80° C. and then cooling it. This will be used to release beauty care ingredients to the skin.

[0055] Generally, when hy...

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Abstract

This invention is about temperature sensitive state-changing hydrogel composition and its method of production that consists of Branched Gel Polymer 1-10 wt %, Electrolyte Gel Polymer 0.5-5 wt %, Skin-friendly Enhancements 0.5-5 wt %, Natural Bio Material 1-10 wt %, Aliphatic Polyol 3-30 wt %, Functional Additive 1-10 wt % and water 30-93 wt %. Temperature sensitive hydrogel composition is produced at temperature between 10° C. and 50° C., where hydrogel transforms to a fluid state. When this invented hydrogel composition is contacted with skin, it transforms into a fluid state owing to body temperature. Then the ingredient or medication in hydrogel can efficiently and evenly penetrate into the skin.

Description

SHORT DESCRIPTION OF FIGURES [0001]FIG. 1 shows the viscosity of the Hydrogel composition measured at various temperatures. [0002]FIG. 2 shows that the hydrogel is formed by two gel type Polymers. Part (a) shows that physical bond of the branched polymer and electrical bond of the electrolyte gel polymer exists together. Part (b) shows the fluid state of the polymers where electrical bond of the electrolyte gel polymer exists but the physical bond of the branched gel polymer does not exist. [0003]FIG. 3 shows the skin care hydrogel sheet that was produced using invented hydrogel composition. Part (a) is the base that is made out of rayon textile and part (b) is the invented Hydrogel.DETAILED DESCRIPTION OF THE INVENTION Purpose of the Invention Technical Field and Traditional Technique [0004] This invention is about the temperature sensitive state-changing Hydrogel composition and the method for its preparation. In detail, it is the Hydrogel composition and its method of production ...

Claims

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Application Information

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IPC IPC(8): A61K8/02A61K8/04A61K8/34A61K8/73A61K9/00A61K9/06A61K9/14A61K9/70A61K36/16A61K36/82A61K36/886A61Q19/00G06K9/34
CPCA61K8/0208A61K8/042A61K8/345A61K8/73A61K8/736A61Q19/00A61K9/7007A61K2800/24A61K2800/54A61K2800/594A61K9/06
Inventor SON, TAEWONOH YOO, HYUNSUNG, CHANGMOKIM, PAUL
Owner UGENIC
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