Method and apparatus for sealing medicinal capsules

Abstract

A method of sealing parts of a plastic capsule by forming a weld seam in an overlapping region of the parts of the capsule, wherein the capsule comprises a capsule cap having an open end and a capsule body having an open end, the method comprising: (a) holding the capsule cap and the capsule body in a capsule holder comprising a first holding part and a second holding part which can be guided synchronously with one another, wherein the first holding part interlockingly surrounds the capsule cap and the second holding part interlockingly surrounds the capsule body; (b) closing the capsule holder holding the capsule cap and the capsule body so that the open end of the capsule cap and the open end of the capsule body form a sealed cavity therebetween and form an overlapping region, wherein the overlapping region is not covered by the capsule holder, to obtain a closed capsule; and (c) welding the closed capsule using an energy beam of hot gas or laser light on the overlapping region by forming the weld seam thereon. The capsules produced by the process according to the invention are disposable capsules and preferably contain a single dose of a pharmaceutical formulation in the form of a powder or liquid suitable for inhalation and are suitable, by their form and function, for use in powder inhalers or liquid nebulizers for producing aerosols. Aerosols thus produced can be inhaled, for example, in order to administer a pharmaceutical formulation to the lungs.

Description

RELATED APPLICATIONS [0001] This application claims priority benefit from U.S. application Ser. No. 10 / 201,443, filed Jul. 23, 2002, which claims benefit under 35 U.S.C. § 119(e) of prior provisional application Ser. No. 60 / 363,657, filed Mar. 12, 2002, is hereby claimed.FIELD OF THE INVENTION [0002] The present invention relates to a new method of sealing plastic capsules or inhalers, inhalation capsules thus produced, and an apparatus which is specially adapted to carry out the process according to the invention. The capsules produced by the process according to the invention are disposable and preferably contain a single dose of a pharmaceutical formulation in the form of a powder or liquid intended to be administered by inhalation and are suitable by their form and function for use in powder inhalers or liquid nebulizers for producing aerosols. Aerosols thus produced can be inhaled, for example, in order to administer a pharmaceutical formulation to the lungs. BACKGROUND OF THE ...

AI Technical Summary

Benefits of technology

[0020] A further objective is to connect the individual parts of a plastic capsule to one another so that they cannot be separated again without damaging the capsule. This makes it easier for the user to tell that the capsules have not already been opened.

[0128] The advantage of the capsules according to the invention is that they have a very low steam permeability, particularly at the seam, and are therefore suitable for use in various climatic regions, e.g., in climatic region 3 with a high relative humidity, without any impairment of the pharmaceutical quality of the formulation. These capsules also have various advantages at other stages of the life of the capsule from its manufacture to its use, in terms of its usability as a carrier of pharmaceutical preparations, the method of administering the contents, the durability of the contents, and / or the suitability of the capsules for use in various countries. One other advantage of the capsule materials according to the invention is that they do not have a tendency to bind powdered materials to themselves, so that precise metering of the fine fraction destined for the lungs is made easier.

Problems solved by technology

It has now been found that these welding processes cannot readily be transferred to the welding of the capsule halves described in WO 00 / 07572.

The limiting conditions mentioned above, which prevent the simple transfer of the methods known from the prior art to capsules for inhalation, include the fact, for example, that the capsules are filled with a pharmaceutical formulation the pharmaceutical quality of which must not be impaired during the welding process.

If the conventional methods are applied to such a capsule, holes will rapidly be burnt into the capsule during the welding process, particularly in those parts of the capsule which are outside the area being welded.

In these parts, the capsule can more easily be damaged by the welding process.

There is also the danger that if the capsule walls are too thick, any weld seam at the junction will not be properly sealed.