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Immunization for Ebola virus infection

a technology for ebola virus and immune response, applied in the field of ebola virus vaccines, can solve the problems of ineffective immune response elicitation by traditional active and passive immunization methods, and achieve the effect of preventing the spread of ebola virus

Inactive Publication Date: 2005-12-22
NABEL GARY +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0005] The present invention also provides methods for immunizing a subject against disease caused by infection with Ebola virus comprising administering to the subject an immunoeffective amount of an Ebola virus vaccine. Administration can be by any of the routes normally used for gene therapy. In a preferred method, the Ebola virus vaccine is administered by intramuscular injection. The genetic immunization methods of the present invention provide protective immunity against disease caused by infection with Ebola virus.

Problems solved by technology

Previous attempts to elicit protective immune responses against Ebola virus using traditional active and passive immunization approaches have, however, not succeeded.

Method used

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  • Immunization for Ebola virus infection
  • Immunization for Ebola virus infection

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I. Results

[0048] Immune response to viral gene products in mice. To characterize immune responses to selected Ebola virus proteins, eukaryotic expression vector plasmids were injected into mice. The cytomegalovirus (CMV) immediate early region 1 enhancer was used to stimulate transcription because ft directs high levels of gene expression in muscle. Manthorpe, M. et al., Hum. Gene. Ther. 4:419-431 (1993). cDNAs encoding an abundant structural protein, the major viral nucleocapsid phosphoprotein (NP), the secreted glycoprotein (sGP), or the membrane-associated glycoprotein (GP) were inserted. Alternative forms of GP were chosen because it had been postulated that the transmembrane protein contained a protein sequence motif also found in oncogenic retroviruses that might suppress immune responses. Burkreyev, A. A. et al., FEBS. Lett. 323:183-187 (1993); Cianciolo, G. J. et al., Science 230:453-455 (1985); Harris, D. T. et al., J. Immunol. 138:889-894 (1987); Volchkov, V. E. et al., ...

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Abstract

Ebola virus vaccines comprising nucleic acid molecules encoding Ebola viral proteins are provided. In one embodiment, the nucleic acid molecule encodes the transmembrane form of the viral glycoprotein (GP). In another embodiment, the nucleic acid molecule encodes the secreted form of the viral glycoprotein (sGP). In yet another embodiment, the nucleic acid molecule encodes the viral nucleoprotein (NP). Methods for immunizing a subject against disease caused by infection with Ebola virus are also provided.

Description

FIELD OF THE INVENTION [0001] The present invention relates generally to viral vaccines and, more particularly, to Ebola virus vaccines and methods of protecting against disease caused by infection with Ebola virus. BACKGROUND OF THE INVENTION [0002] The Ebola viruses, and the genetically-related Marburg virus, are filoviruses associated with outbreaks of highly lethal hemorrhagic fever in humans and primates in North America, Europe, and Africa. Peters, C. J. et al., Filoviridae: Marburg and Ebola Viruses. in Fields Virology. (eds., Fields, B. N., Knipe, D. M. & Howley, P. M.) 1161-1176 (Philadelphia, Lippincott-Raven, 1996); Peters, C. J. et al, Semin. Virol. 5:147-154 (1994). Ebola viruses are negative-stranded RNA viruses comprised of four subtypes, including those described in the Zaire, Sudan, Reston, and Ivory Coast episodes. Sanchez, A. et al., PNAS (USA) 93:3602-3607 (1996). Although several subtypes have been defined, the genetic organization of these viruses is similar, e...

Claims

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Application Information

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IPC IPC(8): C07K14/08
CPCA61K2039/53C12N2760/14122C07K14/005
Inventor NABEL, GARYSANCHEZ, ANTHONY
Owner NABEL GARY
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