The invention relates to a natural
sericin encapsulated mesoporous
silicon nano-carrier and a preparation method and application thereof to the field of tumor treatment. The preparation method comprises the steps of preparing pure
sericin solids; preparing mesoporous
silicon nano-particles; preparing aminated, formylated or dual-sulfurated mesoporous
silicon nano-particles with regular pore passage; preparing
drug-loaded aminated, formylated or dual-sulfurated mesoporous silicon nano-particles; preparing a pH /
protease or reduction /
protease dual-responsiveness
sericin / mesoporous silicon composite multifunctional
control system. The natural sericin encapsulated mesoporous silicon nano-carrier and the preparation method and the application thereof have the advantages that the operation is simple to perform, the raw materials are simple and convenient to obtain, the cost is low, the universal applicability is high, no special complex equipment is needed and the like. The nano composite
system prepared by adopting the method fully utilizes the characteristics of the sericin on the outer layer and the mesoporous silicon nano-particles on the inner layer, has pH /
protease or reduction / protease dual responsiveness, has multiple functions of inhibiting
tumor cells, monitoring nano-particle positioning and
drug release in real time and the like, is high is
drug loading capacity, is good in
biocompatibility and has a wide application prospect in the field of tumor diagnosis and treatment, especially in the aspect of solving multi-
drug resistance of tumors.