The invention provides a testing device and a method applicable for spacecraft high-stability pointing control. The testing device comprises a base, an air bearing, an instrument platform, a spacecraft pointing unit, a spacecraft attitude control unit, a platform data instruction transmitting-receiving system, a mark point, a target measuring head unit, a reflection prism, a counteractive momentum wheel system, an image processing unit, a photoelectric auto-collimator, a laser tracker, an off-platform data instruction transmitting-receiving system and a camera. According to the device and the method, the characteristics of a micro-interference moment environment are simulated by fully using the air bearing; as the high-precision position and attitude measuring techniques of equipment such as the image measuring unit, the laser tracker and the photoelectric auto-collimator are combined, the goal of spacecraft high-stability pointing control test can be realized; the precision is high; the stability is good; and the engineering realization is facilitated. The device and the method can be used for a high-precision pointing control test on spacecraft such as various high-precision weather and military reconnaissance satellites and space-based offense and defense platforms.