The invention relates to a numerical simulation method for dynamic analysis of a large-scale building structure, in particular to a fully explicit method without diagonalization of a damping matrix, with a certain method damping, with a large stable step size, with a third-order accuracy and self-starting. The steps are as follows: Firstly, the large-scale building structure is discretized by spatial finite element method, and the equations of motion of the discrete system are derived; 2, selecte an analysis step length according to that short period of the system; 3, calculate that displacement ui and the velocity vi at the time ti on the i-th time step step by step; Fourth, calculate the displacement with high order accuracy shown in the description, Speed shown in the descriptio, and calculate acceleration shown in the descriptio; Compared with the common explicit dynamic analysis methods such as the central difference method, It is suitable for off-diagonal damping matrix and non-linear damping system, can restrain false high frequency mode, has long stability interval, high precision and fast convergence, self-starting and other characteristics, and the operation steps are simple, easy to implement, and has strong engineering application value.