Pad base for transdermal administration and needle

Inactive Publication Date: 2006-06-15
MEDRX CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0019] Further, the administration condition of a drug such as instantaneous effect and time-release property can be also changed by variously selecting the content form of a drug in the minute needle from among those in which a drug is sealed, those in which a drug is injected in a tube whose one end is opened, those in which a drug is kneaded in the biodegradable resin of the min

Problems solved by technology

The reason why a thick needle is used in a conventional MicroPatch method as described above is that if a long thin minute needle is used, it may fracture easily and remain in the skin, and there is a there is a fear that bad influence to

Method used

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  • Pad base for transdermal administration and needle
  • Pad base for transdermal administration and needle
  • Pad base for transdermal administration and needle

Examples

Experimental program
Comparison scheme
Effect test

Example

Examples 1 to 3

[0044] As a section bar for molding the minute needles, a section bar in which stainless steel wires (thin metal wires) having a length of about 30 mm and a diameter φ of 280 μm were vertically inserted by 5 wires in longitudinal and by 6 wires in a reticular pattern at an interval of 2 mm in a rubber plate was prepared. Then, the edges of stainless steel wires of the above-mentioned section bar were perpendicularly brought in contact with the bottom of a stainless steel dish and, 3 ml of a chloroform solution containing polylactic acid with a molecular weight of 101700 was poured in the stainless steel dish. After that, these were left alone, chloroform was evaporated by naturally drying and the polylactic acid was solidified. Then, the stainless steel wires were taken out from the stainless steel dish to obtain a pad base for endermism. Further, solutions with 5, 6 and 7% by weight as the concentration of polylactic acid in the above-mentioned chloroform solution c...

Example

Examples 4 to 6

[0046] A similar section bar of the minute needles as the above-mentioned Examples 1 to 3 was used and the edges of stainless steel wires of the above-mentioned section bar were perpendicularly brought in contact with the bottom of a stainless steel dish. 3 ml of a chloroform solution containing polylactic acid with a molecular weight of 67400 was poured in the stainless steel dish, left alone, and the polylactic acid was solidified by natural drying. Then, the stainless steel wires were taken out from the stainless steel dish to obtain a pad base for endermism. Further, solutions with 10, 11 and 12% by weight as the concentration of polylactic acid in the above-mentioned chloroform solution containing polylactic acid were prepared, and pad bases which were obtained for the respective solutions were referred to as Examples 4, 5 and 6.

[0047] Any of the above-mentioned Examples 4 to 6 was a pad base for endermism which had a plural number of the minute needles with a ...

Example

Examples 7 to 9

[0048] A similar section bar of the minute needles as the above-mentioned Examples 1 to 3 was used and the edges of stainless steel wires of the section bar were perpendicularly brought in contact with the bottom of a stainless steel dish. 3 ml of a chloroform solution containing polylactic acid with a molecular weight of 258700 was poured in the stainless steel dish, left alone, and the polylactic acid was solidified by natural drying. Then, the stainless steel wires were taken out from the stainless steel dish to obtain a pad base for endermism. Further, solutions with 1, 2 and 3% by weight as the concentration of polylactic acid in the above-mentioned chloroform solution containing polylactic acid were prepared, and pad bases which were obtained for the respective solutions were referred to as Examples 7, 8 and 9.

[0049] Any of the above-mentioned Examples 7 to 9 was a pad base for endermism which had a plural number of the minute needles with a shape as shown in ...

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Abstract

The object of the present invention is to provide a pad base for endermism which hardly causes bad influence on organism even if a needle fractures in the skin and remains in the MicroPatch method. It is the pad base for endermism in which a minute needle 1 is installed upright on the skin side of a patch base 2 for skin. The minute needle 1 is formed from a biodegradable resin and is composed so as to be able to be injected an administering drug in a hollow center of an axle portion (a hollow portion 3). Even if the injection needle fractures and remains in the skin, the minute needle 1 is decomposed in vivo because it is made of a biodegradable resin; therefore, there is little bad influence is to organism.

Description

TECHNICAL FIELD [0001] The present invention relates to a pad base for endermism used when percutaneously administrating a drug which acts on organism in vivo and an injection needle. The pad base is a portion assuming the percutaneous administration of a drug in a pad for percutaneous medication. The pad for percutaneous medication is an article covering the pad base with, for example, a pressure-sensitive adhesive sheet from the reverse of the skin side, and the like. When the pad base for endermism is used, the pad base side is pasted on the skin. BACKGROUND ART [0002] The skin functions as a barrier for protecting the body and inhibits the invasion of a foreign substance in organism. Specifically, the stratum corneum of the outermost layer which is directly brought in contact with the foreign substance assumes the great role as a barrier. To be sure, although the digestive tract is the same as the skin from the viewpoint of being directly brought in contact with the foreign subs...

Claims

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Application Information

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IPC IPC(8): A61K9/70A61M37/00
CPCA61M37/0015A61M2037/003A61M2037/0038A61M2037/0053
Inventor MAENOSONO, SHINYASUZUKI, YASUSHIAKITOMO, HIROSHIHAMAMOTO, HIDETOSHIISHIBASHI, MASAKI
Owner MEDRX CO LTD
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