Treatment and prevention of elevated homocysteine

Inactive Publication Date: 2006-12-14
BIOGENIC INNOVATIONS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0029] The present method addresses this dilemma by providing means of treating and preventing conditions caused or exacerbated by, or associated with, elevated homocysteine levels. By providing the dietary supplement of the present method, one which has little or no side effects and is capable of addressing the causes and symptoms of conditions caused or exacerbated by, or associated with, elevated homocysteine levels, people are able to receive a treatment or a preventative for a disease or diseases from which they unknowingly suffer or are at risk from suffering.

Problems solved by technology

High dietary consumption of methionine, which can be found in meats and dairy products, can result in the overproduction of homocysteine.
If the cofactors are lacking, homocysteine will build up to toxic levels.
Although this is “normal,” it is not necessarily healthy.
Homocysteine is, in fact, toxic to the medulloblastoma cells of the brain.
However, many people suffer from conditions caused or exacerbated by, or associated with, elevated homocysteine levels and do not receive treatment since the symptoms of these diseases are not easily recognized.
Thus, by the time a person finally suffers recognizable symptoms of one of these diseases or are diagnosed, the severity of the disease may have become life-threatening.

Method used

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  • Treatment and prevention of elevated homocysteine

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Embodiment Construction

[0033] The method of the present invention contemplates the use of dimethyl sulfone as a methyl donor in the remethylation of homocysteine to methionine. Dimethyl sulfone (DMSO2, methylsulfone, methylsulfonylmethane, MSM) is a nutritional supplement comprising sulfur, methyl groups, and oxygen. Dimethyl sulfone may be administered by multiple routes, including oral, intravenous, and topical.

[0034] In 2005, a study was conducted to determine the efficacy of dimethyl sulfone in the treatment of pain and physical function impairment due to osteoarthritis. Patients were given dosage of 6 g of dimethyl sulfone (Distilled MSM microprill (OptiMSM®, Cardinal Nutrition, Vancouver, Wash.)) per day in a stepwise approach. In week 1, dosages started with 2 g / day in two divided doses for 3 days, and then increased to 4 g / day for 4 days. Week 2, increased to 6 g / day. In the control group, a placebo was administered that consisted of inert ingredients and that was indistinguishable in color, size...

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Abstract

A method for reducing elevated levels of homocysteine in a person comprising the steps of measuring the level of homocysteine in a person; detecting an elevated level of homocysteine in the person; and responsive to said step of detecting, administering to said person a nutritional supplement comprising dimethyl sulfone.

Description

RELATED APPLICATIONS [0001] Not applicable. Field of the Invention [0002] This invention relates to the use of dimethyl sulfone preparations and methods for using such preparations for supporting normal homocysteine levels and for preventing and treating elevated homocysteine levels in the blood. More particularly, it relates to the administration of dimethyl sulfone by multiple routes, including oral, intravenous, topical, and other routes to reduce homocysteine and to maintain normal homocysteine levels. [0003] The invention also relates to methods for using dimethyl sulfone in combination with other nutritional ingredients, dietary supplements, excipients, foods, beverages, food additives, and drugs for maintenance of normal homocysteine levels. BACKGROUND [0004] Homocysteine is an amino acid formed in the body. It is created by the breakdown of another amino acid, methionine. High dietary consumption of methionine, which can be found in meats and dairy products, can result in th...

Claims

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Application Information

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IPC IPC(8): A61K31/10
CPCA23L1/293A23L1/30A61K31/10A61K45/06A61K2300/00A23L33/30A23L33/10
Inventor APPLETON, JEREMY E.
Owner BIOGENIC INNOVATIONS
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