Treatment and prevention of elevated homocysteine
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[0033] The method of the present invention contemplates the use of dimethyl sulfone as a methyl donor in the remethylation of homocysteine to methionine. Dimethyl sulfone (DMSO2, methylsulfone, methylsulfonylmethane, MSM) is a nutritional supplement comprising sulfur, methyl groups, and oxygen. Dimethyl sulfone may be administered by multiple routes, including oral, intravenous, and topical.
[0034] In 2005, a study was conducted to determine the efficacy of dimethyl sulfone in the treatment of pain and physical function impairment due to osteoarthritis. Patients were given dosage of 6 g of dimethyl sulfone (Distilled MSM microprill (OptiMSM®, Cardinal Nutrition, Vancouver, Wash.)) per day in a stepwise approach. In week 1, dosages started with 2 g / day in two divided doses for 3 days, and then increased to 4 g / day for 4 days. Week 2, increased to 6 g / day. In the control group, a placebo was administered that consisted of inert ingredients and that was indistinguishable in color, size...
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