Modulation of endothelial lipase expression

a technology of endothelial lipase and expression, applied in the field of moduled can solve the problems of no known therapeutic agent which effectively inhibits the synthesis of endothelial lipase, and achieve the effect of modulating the expression of endothelial lipas
US20070020675A1Inactive Publication Date: 2007-01-25IONIS PHARMA INC
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Patent Information

Authority / Receiving Office
US · United States
Current Assignee / Owner
IONIS PHARMA INC
Publication Date
2007-01-25
Estimated Expiration
Not applicable · inactive patent
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Abstract

Compounds, compositions and methods are provided for modulating the expression of endothelial lipase. The compositions comprise oligonucleotides, targeted to nucleic acid encoding endothelial lipase. Methods of using these compounds for modulation of endothelial lipase expression and for diagnosis and treatment of disease associated with expression of endothelial lipase are provided.
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Description

RELATED APPLICATIONS

[0001] This application is a continuation-in-part of U.S. patent application Ser. No. 10 / 319,915, filed Dec. 12, 2002. This application is also a continuation-in-part of U.S. patent application Ser. No. 11 / 036,095, filed Jan. 14, 2005; which is a continuation-in-part of the following U.S. patent applications: Ser. No. 10 / 187,110, filed Jun. 29, 2002; Ser. No. 10 / 303,328, filed Nov. 22, 2002; Ser. No. 10 / 302,028, filed Nov. 21, 2002; Ser. No. 10 / 293,866, filed Nov. 11, 2002; Ser. No. 10 / 316,241, filed Dec. 9, 2002; Ser. No. 10 / 317,401, filed Dec. 11, 2002; Ser. No. 10 / 210,556, filed Jul. 31, 2002; Ser. No. 10 / 210,723, filed Jul. 31, 2002; Ser. No. 10 / 318,389, filed Dec. 11, 2002; Ser. No. 10 / 302,027, filed Nov. 21, 2002; Ser. No. 10 / 300,399, filed Nov. 19, 2002; Ser. No. 10 / 189,429, filed Jul. 3, 2002; Ser. No. 10 / 174,020, filed Jun. 17, 2002; Ser. No. 10 / 177,554, filed Jun. 20, 2002; Ser. No. 10 / 185,035, filed Jun. 28, 2002; Ser. No. 10 / 316,755, filed Dec. 10, 2...

Claims

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