Fluid for peritoneal dialysis
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experiment 1
Effects of Cyclic Tetrasaccharides and L-Ascorbic Acid 2-Glucoside on the Browning of DF
[0021]According to the compositions described in Table 1, DFs comprising powdery crystalline CNN pentahydrate, powdery crystalline CMM pentahydrate, or L-ascorbic acid 2-glucoside (reagent grade, commercialized by Hayashibara Biochemical Laboratories Inc., Okayama, Japan) were prepared. These DFs were respectively placed in glass bottles, tightly sealed, and sterilized at 121° C. for 40 minutes. Successively, the browning of DFs and the formation of 5-hydroxymethyl-furfural were judged by macroscopically and the increase of absorbance at 284 nm. The results were also shown in Table 1. A DF comprising glucose, shown in Table 1, was used as a control.
TABLE 1Composition (g / 1000 mL)IngredientDF1DF2DF3DF4DF5ControlSodium chloride5.385.385.385.385.385.38Sodium lactate7.47.47.47.47.47.4Calcium chloride0.260.260.260.260.260.26dihydrateMagnesium chloride0.050.050.050.050.050.05hexahydrateCNN250012.500(d.s...
experiment 2
Effect of a Cyclic Tetrasaccharide on the Body Fluid Removability of DF (1)
[0023]Experiments, examining the effects of a cyclic tetrasaccharide on the body fluid removability of DF, were carried out using dialysis tube as follows:
[0024]According to the compositions shown in Table 2, DFs comprising glucose or CNN are prepared, respectively. Into a dialysis tube (Molecular weight cut off: 15,000 daltons; diameter: 16 mm; length: 70 mm), 1.5 milliliters each of the DF was poured and sealed using a closer, and then put into one liter of a dialyzing solution, prepared by admixed sodium chloride and dextran (Molecular weight: 60,000 to 90,000 daltons; commercialized by Wako Pure Chemical Industries Ltd., Osaka, Japan) with purified water to give concentrations of 9 g / L and 6 g / L, respectively, for dialysis. The fluid volumes in the dialysis tube at one to 14 hours after the start of dialysis were examined by measuring the weight of the tube. In the experiment, three dialysis tubes were us...
experiment 3
Effects of Cyclic Tetrasaccharides on the Body Fluid Removability of DF (2)
[0026]Experiments, examining the effects of a cyclic tetrasaccharide on the body fluid removability of DF, were carried out using rats as follows:
[0027]Into the electrolyte solution with a concentration described in Table 2, CNN, CMM or L-ascorbic acid 2-glucoside was dissolved, and DFs comprising 7.5% (w / v) of CNN (DF1), 7.5% (w / v) of CMM (DF2), or 6.7% (w / v) of L-ascorbic acid 2-glucoside (DF3) were prepared, respectively. As a control, glucose was dissolved into the same electrolyte solution to give a concentration of 3.86%, on a dry solid basis, to make into a DF (Control). Successively, 10 milliliters each of DFs was administrated to peritoneal cavity of CD (SD) IGF rat (age in 7 to 8 weeks, male, weight: 256 to 317 grams, commercialized by Charles River Laboratories Japan, Inc., Kanagawa, Japan), pre-fasted for four hours and anesthetized by ether, using a 10 ml-capacity injection syringe with a 21-gaug...
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