Compositions and methods of promoting wound healing

a technology applied in the field of composition and wound healing, can solve the problems of limited success in accelerating wound healing with pharmacological agents, affecting the healing effect of wounds, so as to promote or accelerate wound healing, inhibit cell apoptosis, and mitigate scar formation and/or around wounds.

Inactive Publication Date: 2010-10-28
THE CLEVELAND CLINIC FOUND +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0016]The amount of SDF-1 in the wound can also be an amount effective to promote or accelerate wound healing, mitigate scar formation of and / or around the wound, inhibit apoptosis of cells surrounding or proximate the wound, and / or facilitate revascularization of the wounded tissue. In an aspect of the invention, the SDF-1 can be in the form of protein or plasmid that when administered to a cell proximate the wound promotes expression of SDF-1 from the cells.

Problems solved by technology

Wounds (i.e., lacerations or openings) in mammalian tissue result in tissue disruption and coagulation of the microvasculature at the wound face.
While this new blood vessel growth (angiogenesis) is necessary for the healing of wound tissue, angiogenic agents generally are unable to fulfill the long-felt need of providing the additional biosynthetic effects of tissue repair.
Despite the need for more rapid healing of wounds (i.e., severe burns, surgical incisions, lacerations and other trauma), to date there has been only limited success in accelerating wound healing with pharmacological agents.

Method used

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  • Compositions and methods of promoting wound healing
  • Compositions and methods of promoting wound healing

Examples

Experimental program
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Effect test

example 1

Stromal Cell-Derived Factor-1 Release in Alginate Scaffolds

Characterization and Ability to Accelerate Wound Healing

[0102]We hypothesized that a slow-release delivery of either SDF-1 protein or plasmid would increase its effectiveness on wound healing. Therefore, we employed a clinically-relevant delivery system, an alginate scaffold, to deliver SDF-1 over time to a porcine acute surgical wound model. We characterize SDF-1 delivery using alginate scaffolds in vitro, and demonstrated the potential for therapeutic benefit in vivo by using the scaffolds to deliver SDF-1 protein and plasmid to acute surgical wounds.

Preparation of Scaffolds for In Vivo Application

[0103]For the in vivo application, custom 1 cm×6 cm alginate scaffolds were produced by the same process described above. Scaffolds were then loaded with SDF-1 plasmid (n=6), SDF-1 protein (n=10), or phosphate buffered saline (PBS) (n=4) by the process described below.

[0104]For the SDF-1 plasmid scaffolds, a plasmid was created b...

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Abstract

A method of treating a wound in a subject includes administering directly to the wound or an area proximate the wound an amount of SDF-I effective to promote healing of the wound of the subject.

Description

RELATED APPLICATION[0001]This application claims priority from U.S. Provisional Application No. 61 / 013,878, filed Dec. 14, 2007, the subject matter, which is incorporated herein by reference.FIELD OF THE INVENTION[0002]The present invention relates to composition and methods of promoting wound healing in subject.BACKGROUND OF THE INVENTION[0003]Wounds (i.e., lacerations or openings) in mammalian tissue result in tissue disruption and coagulation of the microvasculature at the wound face. Repair of such tissue represents an orderly, controlled cellular response to injury. All soft tissue wounds, regardless of size heal in a similar manner. Tissue growth and repair are biologic systems wherein cellular proliferation and angiogenesis occur in the presence of an oxygen gradient. The sequential morphological and structural changes which occur during tissue repair have been characterized in great detail and have in some instances been quantified (Hunt, T. K., et al., “Coagulation and macr...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K38/20A61K38/00A61P17/02
CPCA61K38/00A61K38/195C07K14/522A61K48/00A61P17/02
Inventor PENN, MARC S.KIEDROWSKI, MATTHEWARAS, RAHULPASTORE, JOSEPH
Owner THE CLEVELAND CLINIC FOUND
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