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Compositions and methods for treatment of vitiligo

a technology of vitiligo and compositions, applied in the field of skin compositions, can solve the problems of psychological and social problems, undesirable side effects of retin-a, etc., and achieve the effect of reducing discoloration and enlargement of vitiligo spots

Inactive Publication Date: 2011-06-23
0901911 B C UNLIMITED LIABILITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0006]In one aspect of the invention, the composition contains rapamycin in a cosmeceutically acceptable medium / vehicle that functions to reduce T-cell degradation of melanocytes and lessen the visual signs of vitiligo.

Problems solved by technology

However, retin-A has some undesirable side effects and requires monitoring of sun exposure while treating skin.
As this condition affects the skin and is readily visible to the public eye, there are many psychological and social problems that can result.

Method used

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  • Compositions and methods for treatment of vitiligo

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0034]As shown in FIG. 1, Human Hepatocarcinoma, HH, cells were treated with increasing doses of rapamycin (0.1-100 uM) and the protein expression profile was analyzed by Western blot. The rapamycin treatment resulted in increased expression of pAcc (phosphorylated acetyl-CoA carboxylase), slightly increased expression of peEF2 (phosphorylated eukaryotic elongation factor 2) and decreased expression of pS6 (phosphorylated ribosomal protein S6). The expression levels of Actin are maintained and serve as a loading control. The increased expression of pAcc and peEF2, and the decreased expression of pS6 illustrate an inhibition of T-cells.

example 2

Vitiligostop

[0035]Natural sources of anti fungal agents help to stop the rejection of melanin producing cells which causes the depigmentation of the skin. Vitilogstop is not a cure, but provides a noticeable diminishment of discoloration and enlargement of vitiligo spots usually after three months. Combined with other active ingredients, stimulation of new melanin occurs over time. Apply twice a day on affected sites. The cream may oxidize and darken with time but will remain effective throughout use.

VitilgostopAmount per 10 gmsRapamycin15milligramsFibroblast Growth Factor 21.5microgramsTromethamine0.5%Glutathaion Peroxides30milligramsCatalase30milligramsVitamin E500milligramsVehicle10grams

formulation example

[0036]A 0.4 mg / ul Rapamycin composition is made in DMSO as a stock solution, from which an aliquot of 187.5 uls of the stock solution is added to 200 gms of lotion or cosmeceutically acceptable medium and mixed thoroughly. An FGF composition is made following a similar protocol for a cosmeceutically acceptable medium and mixed thoroughly. Additional concentrations can be made from a concentrated stock solution by methods known to one of ordinary skill in the art. The cosmeceutical formulation (lotion) can be stored at ambient temperature for topical use on those areas of the skin wherein additional lipid production is desired.

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Abstract

Compositions and methods are disclosed for treating vitiligo and promoting the formation of collagen.

Description

CROSS REFERENCE TO RELATED APPLICATIONS[0001]This application claims priority to U.S. Provisional Patent Application No. 61,288,688 filed on Dec. 21, 2009, entitled “Compositions and Methods for Treatment of Vitiligo” by Sarah Bacus, hereby incorporated by reference.TECHNICAL FIELD[0002]The present invention relates to a novel skin composition that stops progression of vitiligo. The invention further relates to a composition containing a compound functioning to inhibit T-cell killing in the melanocytes. More specifically, the invention relates to a composition containing rapamycin as an active ingredient. In addition, the invention can contain fibroblast growth factor as an active ingredient. The invention further relates to a composition for promoting the formation of collagen in the skin, wherein the composition comprises the aforementioned compound or compounds. The invention also relates to a method of treating related skin signs of aging (hollowing or sagging of skin) through u...

Claims

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Application Information

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IPC IPC(8): A61K31/436A61K38/18A61K38/44A61P17/00C12N5/0783
CPCE01C23/16A61K31/133A61K38/44A61K31/436A61K38/1825A61K31/355A61P17/00
Inventor BACUS, SARAH
Owner 0901911 B C UNLIMITED LIABILITY