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Micro-calorimeter apparatus

a micro-calorimeter and apparatus technology, applied in the field of micro-calorimeters, can solve the problems of difficult to combine the demands of the devices to be manufactured, the material and method used for electronic components require very high temperatures, and the cost of designing and fabricating a custom integrated biosensor unit is significan

Inactive Publication Date: 2012-12-13
SENZIME
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The present invention proposes a new biosensor unit and calorimeter apparatus that separates the biological parts from the electronic parts, using a new thermal transducer technology. This simplifies the manufacturing process of the biosensor unit and makes it easier to connect it to the calorimeter. The calorimeter is designed to accommodate a continuous flow of bio fluid through the reaction chamber, and the biosensor unit is designed to fit snugly between the Peltier elements of the calorimeter. The technical effects of this invention include improved accuracy, simplified manufacturing process, and improved performance of the calorimeter.

Problems solved by technology

It has turned out that there is a significant cost of designing and fabricating a custom integrated biosensor unit that includes both the biological sensing part and the necessary electronic elements.
One major reason for this is that the materials and methods used for electronic components require very high temperatures, which temperature levels are incompatible with the fabrication of the biological part.
It has turned out to be difficult to combine these contradicting demands of the devices to be manufactured.

Method used

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Embodiment Construction

[0030]The principle of calorimetry, i.e. the detection of heat of reaction, on which the present invention is based is well known since many years.

[0031]The apparatus according to the invention is schematically illustrated in FIG. 1 and is generally described with 1. The apparatus comprises a thermostated space or compartment 2, formed from, or defined by, two opposing blocks 3,4 and a cylinder 5, where the block 3 is axially moveable a short distance in relation to the cylinder 5 and-the block 4 is fixed to the cylinder 5. The two blocks and the cylinder is separated from each other by separating members, here small washers 6, thereby forming an insulating air gap between them. Each part is individually temperature controlled. The entire device is enclosed in an insulating house 7, see FIG. 2. The two blocks are provided with, holding pins 8a,8b made of a material with low heat conductivity, preferably plastics onto which are placed two heat sinks 9,10, heat sink 9 being slightly m...

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Abstract

A micro-calorimeter apparatus includes a thermostated housing (3,4,5); a pair of essentially flat heat sinks (9,10), suspended in the housing (2) and thermally floating relative to the environment inside the housing (3,4,5). The heat sinks (9,10) are arranged with their surfaces facing each other. A pair of Peltier elements (11) are thermally attached to the heat sinks (9,10), one element (11) on each heat sink (9,10), on the facing surfaces, forming a gap between them for the accommodation of a generally flat biosensor unit (12).

Description

[0001]The present invention relates to biosensor systems in general, and in particular to a calorimetric type of system, especially for enzymatic reactions.BACKGROUND OF THE INVENTION[0002]The term biosensor is commonly referred to as a measuring device that combines a biological sensing part is close proximity to a non-biological transducer which converts the biochemical or electrochemical Information produced in the biological part into a measurable signal.[0003]The most commonly employed transducer in current biosensor instruments (e.g. a clinical analyser) today is electrochemically based. An clinical analyser is often used in connection with a biosensor unit (one-time use), which before operation, is connected to the analyser. The biosensor unit contains both the biological and the electronic transducer. It has turned out that there is a significant cost of designing and fabricating a custom integrated biosensor unit that includes both the biological sensing part and the necess...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): G01N25/24C12M1/34G01K17/00G01N25/48
CPCG01K17/006G01N25/4873G01N25/4826
Inventor CARLSSONROSENGREN, KJELL
Owner SENZIME