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Anti-aging composition for vitalization of retinoic acid receptor that contains mixed extract of chinese matrimony vine and pine needles as effective component

Inactive Publication Date: 2014-08-28
AMOREPACIFIC CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The present invention is a composition that contains a mixture of Lycium chinense fruit extract and pine needle extract. This composition has been found to reduce wrinkles and signs of aging by activating retinoic acid receptor and inhibiting the expression of collagenase. The composition is safe and can be used in various applications, such as cosmetic or drug products. The method for preparing the mixture involves washing, drying, and extracting the ingredients. The composition is effective in inhibiting skin aging and promoting the production of collagen.

Problems solved by technology

However, because tretinoin is fat-soluble, it has low absorbability.
Also, it is unstable in the living body, is irritant to the skin, and may cause some side-effects such as skin dryness, wounds, scraping, etc. during the latent period.
Therefore, there are many problems in using tretinoin as a main component for medicines and cosmetics (U.S. Pat. No. 4,677,120).
On the other hand, retinol that is vitamin A can hardly be used because it is unstable to light, oxygen, heat, lipid peroxides, or water.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

Preparation of Lycium chinense Fruit Extract

[0019]Lycium chinense fruits were washed with purified water, washed and finely powdered. 200 g of the Lycium chinense fruit powder was added to 1 liter of an aqueous solution of 70% ethanol and extracted by heating for 12 hours in an extractor equipped with a cooling condenser. The extract was filtered through 300-mesh filter cloth, and the filtrate was allowed to stand at 4˜15° C. for 7 days, and then filtered through Whatman No. 2 filter paper.

[0020]The filtered extract was placed in a 3-liter separatory funnel, and 1 liter of ethyl acetate was added thereto. Then, the solution was mixed well by shaking. After the solution was completely separated into two layers, the upper layer (ethyl acetate layer) was collected. The lower layer (aqueous layer) was extracted twice more using a separatory funnel.

[0021]The separated upper layers were combined with each other and concentrated under reduced pressure at 50° C. using a distillation apparat...

example 2

Preparation of Pine Needle Extract

[0022]Pine needles were washed with purified water, washed and finely powdered. 200 g of the pine needle powder was added to 1 liter of an aqueous solution of 70% ethanol and extracted by heating for 12 hours in an extractor equipped with a cooling condenser. The extract was filtered through 300-mesh filter cloth, and the filtrate was allowed to stand at 4˜15° C. for 7 days, and then filtered through Whatman No. 2 filter paper.

[0023]The filtered extract was placed in a 3-liter separatory funnel, and 1 liter of ethyl acetate was added thereto. Then, the solution was mixed well by shaking. After the solution was completely separated into two layers, the upper layer (ethyl acetate layer) was collected. The lower layer (aqueous layer) was extracted twice more using a separatory funnel.

[0024]The separated upper layers were combined with each other and concentrated under reduced pressure at 50° C. using a distillation apparatus equipped with a cooling con...

formulation example 1

Milk Lotion

[0035]According to the composition shown in Table 3 below, milk lotion can be prepared by a conventional method.

TABLE 3ComponentsContent (wt %)Glycerin8.0Butylene glycol4.0Hyaluronic acid extract5.0Beta-glucan7.0Carbomer0.1Mixture of Lycium chinense extract and1.0pine needle extractCaprylic / capric triglyceride8.0Squalane5.0Cetearyl glucoside1.5Sorbitan stearate0.4Cetearyl alcohol1.0Preservativeq.s.Fragranceq.s.Pigmentq.s.Triethanoamine0.1Purified waterBalance

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PUM

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Abstract

The present invention relates to an anti-aging composition that contains a mixed extract of Chinese matrimony vine and pine needles as an effective component. More specifically, the present invention relates to a composition for an external application to the skin, wherein a mixed extract of Chinese matrimony vine and pine needles, which are the natural ingredients, is contained such that excellent anti-aging or wrinkle improvement effects to the skin can be obtained through the vitalization of a retinoic acid derivative.

Description

TECHNICAL FIELD[0001]The present invention relates to an anti-aging composition containing a mixture of Lycium chinense fruit extract and pine needle extract as an active ingredient. More particularly, the present invention relates to an anti-aging composition containing, as an active ingredient, a mixture of Lycium chinense fruit extract and pine needle extract that exhibits an anti-aging effect by activating retinoic acid receptor.BACKGROUND ART[0002]The phenomena of aging are deepened as human beings grow older. Particularly, in the case of the skin, the change is remarkable. The main phenomena of skin aging are an increase in wrinkles, skin thickening, inelasticity, dryness, roughness, spot, etc., which are believed to be caused by skin exposure to sunlight over a long period of time. Such phenomena by sunlight are called photo-aging and are caused by the changes in epidermal and dermal tissues due to the sunlight. It has been reported that photo-aging of the skin may be allevia...

Claims

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Application Information

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IPC IPC(8): A61K8/97A61Q19/08
CPCA61K8/97A61Q19/08A61K8/9767A61K8/9789A61K2800/5922A61K2800/78A61P17/00A61P43/00A61K36/15A61K36/815A61K2236/33
Inventor KANG, YOUNG GYUPARK, JUN SEONGKIM, JEE YEUNNA, YONG JOOPARK, NOK HYUNYEOM, MYEONG HUNCHO, JUN CHEOL
Owner AMOREPACIFIC CORP