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Transgenic mouse expressing human lipoprotein (a) with disabled vitamin c gene and its use as a disease treatment model

a technology of human lipoprotein and vitamin c gene, which is applied in the field of transgenic mouse, can solve the problems of insufficient clinical cardiology effective treatment and low plasma levels

Inactive Publication Date: 2015-03-12
RATH MATTHIAS W
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  • Abstract
  • Description
  • Claims
  • Application Information

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Benefits of technology

The patent describes a method for creating a dual transgenic mammal that lacks the ability to produce vitamin C and expresses human genes for apolipoprotein(a) and apolipoprotein B. This mammal model can be used to study cardio vascular disease and evaluate the effectiveness of drugs and other compounds in treating these diseases. The technical effect of this patent is the creation of a unique animal model that can help researchers better understand and develop treatments for atherosclerosis and related diseases.

Problems solved by technology

Aside from Niacin, there is currently no accepted effective treatment available in clinical cardiology to lower Lp(a) plasma levels or to prevent its deposition inside the vascular wall.

Method used

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  • Transgenic mouse expressing human lipoprotein (a) with disabled vitamin c gene and its use as a disease treatment model
  • Transgenic mouse expressing human lipoprotein (a) with disabled vitamin c gene and its use as a disease treatment model
  • Transgenic mouse expressing human lipoprotein (a) with disabled vitamin c gene and its use as a disease treatment model

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Embodiment Construction

[0029]The invention discloses novel dual transgenic mammal / mouse, method of crossbreeding a dual transgenic mammal (may be a mouse or other animals) and the use of the dual transgenic mammal / mouse for assessing treatment method for cardiovascular and related diseases. The dual transgenic mouse expresses human apolipoprotein (a) and apolipoprotein B-100 genes and produces apolipoprotein (a) and apolipoprotein B-100 as well as complete human lipoprotein (a) particles in this mouse which, simultaneously, does not express L-gulonolactone oxidase (GULO − / −) and, consequently, does not produce vitamin C. This novel dual transgenic mouse is the ideal model for testing pharmaceutical compounds for treatment efficacy and usefulness for Lp(a) modulation with a variety of biological and / or pharmaceutical compounds, including but not limited to, nutrition, pharmaceutical drugs and treatment methods that affect human beings.

[0030]Although the present embodiments have been described with referenc...

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Abstract

The invention discloses novel model of transgenic mammal, a method of crossbreeding transgenic mammal and the use of the transgenic mammal for assessing prevention and / or treatment methods for cardiovascular and other diseases related to lipoprotein(a). The transgenic mammal expresses human apolipoprotein (a) (apo(a)) and human apolipoprotein B-100 (apo B-100) genes and produces human lipoprotein (a), apo (a) and apo B-100 and produces no vitamin C. This novel dual transgenic mammal is the ideal model for testing pharmaceutical compounds for efficacy and usefulness in the prevention and / or treatment of human diseases.

Description

CROSS REFERENCE TO RELATED APPLICATION[0001]This instant application is a continuation of U.S. Utility application Ser. No. 14 / 025,532 filed on Sep. 12, 2013. The pending and now allowed U.S. Utility application Ser. No. 14 / 025,532 is hereby incorporated by reference in its entireties for all of its teachings.FIELD OF TECHNOLOGY[0002]This disclosure relates generally to a transgenic mouse that has been genetically altered to express human lipoprotein (a) and a disabled gene for the expression of Vitamin C. More specifically the two defining human proteins of lipoprotein (a), apolipoprotein (a) and apolipoprotein B-100 gene may be expressed either individually or in combination without the expression of Vitamin C gene. This application contains sequence listing that has been submitted as an ASCII file named RIPLLC018017US1sequence_ST25, the date of creation Sep. 12, 2013, and the size of the ASCII text file in bytes is 2 kb. The dual transgenic mouse embryo referred to as Rath M Huma...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A01K67/027A61K49/00
CPCA01K67/0278A61K49/0008A01K2227/105A01K2217/15A01K2267/0368A01K2267/0337A01K2267/0375A01K67/0276A01K2207/15A01K2217/052A01K2267/03A01K2267/0362C07K14/775C12N9/0006C12N15/8509C12Y101/03008A01K67/0275A01K2217/00A01K2217/05C12N15/90G01N33/92
Inventor RATH, MATTHIAS W.NIEDZWIECKI, ALEKSANDRACHA, JOHN CHANG-EUN
Owner RATH MATTHIAS W
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