Fertilized egg isolate and uses thereof

a technology of fertilized egg and isolate, which is applied in the field of fertilized egg isolate, can solve the problems of affecting social structure and societal economics, affecting the function of patients with depression, and limiting the effect of antidepressants on a subset of depressed patients

Inactive Publication Date: 2017-03-02
UNITED PARAGON ASSOCS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0061]Still other objects and advantages of the present invention will become readily apparent to those skilled in the art from the detailed description, wherein only the preferred embodiments are described, simply by way of illustration. As will be realized, the invention is capable of other and different embodiments, and its several details are capable of modification in various obvious respects, all without departing from the invention. Accordingly, the description and examples below are to be regarded as illustrative in nature, and not as restrictive.

Problems solved by technology

Patients with depression are often impaired in function and frequently have co-morbid disorders such as substance abuse that can be attributed to the underlying depression.
Depression leads to increased utilization of health services and can have a devastating impact on social structure and societal economics.
However, any given antidepressant is only effective in a subset of depressed patients and often only partially so.
However, while one of the major factors in effective antidepressant therapy is maintaining the patient on an adequate dose of medication for an adequate duration, this is often difficult.
Patients who are prepared to take antidepressants often encounter a wide array of side effects which leads them to be non-compliant or to reject therapy entirely.
Most antidepressants have at least some significant side effects and these limit clinicians' capacity to effectively treat many patients.
It is widely acknowledged that the limited efficacy, often unacceptable side effects and physiological factors that may induce or otherwise affect the course of depression make it necessary to continue to search for new compounds with novel pharmacological actions to address the major public health problem of depression.

Method used

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  • Fertilized egg isolate and uses thereof
  • Fertilized egg isolate and uses thereof
  • Fertilized egg isolate and uses thereof

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0062]Fertilized hen eggs that were 8-9 days old were selected. The whole egg was disinfected with 70% ethanol and left in the fume hood to allow the 70% ethanol to evaporate. The eggs were broken and the contents were dropped through a sterile 1.0 min mesh. The shells and filtrate were discarded. The retentate, both solid and liquid, was collected and chilled on ice. The retentate was homogenized at 5° C. The homogenate (slurry) was poured into sterile stainless steel trays, frozen, and freeze-dried. The dried product was pulverized with a grinder. Preservatives 0.5% w / w sodium benzoate and 0.2% w / w potassium sorbate were added to the powder, and the mixture was blended. The finished powder was stored at 2-8° C. (short term) or −20° C. (long term).

example 2

[0063]Chicken embryos were harvested at 8 days old from fertilized hen eggs according to the following method:[0064](i) 24 brown eggs were received;[0065](ii) when cracked open, only 22 of 24 eggs where found fertilized containing the developed embryo (91.6% fertilization rate);[0066](iii) embryos were removed and washed (×2) briefly in sterile PBS and immediately frozen at −20° C. in individual 50 mL (milliliter) test tubes;[0067](iv) 10 test tubes were then freeze dried in a freeze dryer (shelf temp.=−40° C., condenser temp. −52° C.);[0068](v) at the end of the cycle, the individual embryos (while in test tube) were crushed with a sterile glass rod and the resulting powder (1.7 g (grams)) was packaged;[0069](vi) the 12 remaining embryos were pooled in a small beaker and blended with a small amount of water using a hand held blender;[0070](vii) the resulting slurry was immediately frozen and subsequently freeze dried as above.

[0071]Results

[0072]Once dried, the powder (1.7 g) was di...

example 3

[0074]Sixty fertilized eggs (8 day old embryos) were received. The following is a description of the preparation of both the aqueous and the ether isolates.

[0075]All eggs were sprayed with 70% (v / v) ethanol to sterilize the external surface and the eggs were left in the laminar flow hood for the alcohol to evaporate. The eggs were broken and the embryos and the attached clear sac with its clear watery content were carefully separated from the rest of yolk and vascular material. Then, all material, that is, the embryo and clear sacs, was pooled in a beaker that had been chilled on ice. Following the harvest, the material was blended with the help of a hand held blender, resulting in a slurry.

[0076]The resulting slurry (approx. 200 mL) was split into two equal halves; one was used for extraction with water and the second for ether extraction.

[0077]Aqueous Isolate

[0078]To the 100 mL slurry, 100 mL of R.O. water was added and the material was stirred at room temperature for 30 minutes. ...

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PUM

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Abstract

Fertilized egg isolate, methods for preparing the fertilized egg isolate and uses thereof for treating mental health disorders and disease or conditions mediated by or associated with one or more glutamate receptors or by the neurokinin 2 (NK2) receptor.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS[0001]This is a continuation of U.S. application Ser. No. 12 / 812,335, filed Sep. 21, 2010, which is a National Stage Entry of PCT / CA09 / 00019, filed Jan. 9, 2009, which claims the benefit of U.S. Provisional Application No. 61 / 020,541, filed Jan. 11, 2008 and U.S. Provisional Application No. 61 / 033,184, filed Mar. 3, 2008, which are hereby incorporated by reference.FIELD OF THE INVENTION[0002]The invention relates to fertilized egg isolate including that prepared by any of the processes set forth in the description and uses thereof for treating mental health disorders.BACKGROUND OF THE INVENTION[0003]Major depressive disorder (also known as major depression, clinical depression, unipolar depression and unipolar disorder) is very prevalent in the general population. Most recent North American data show a 14.5% lifetime risk of major depression in adults and 8.1% one year prevalence (Results from the 2004 National Survey on Drug Use and Health: Na...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K35/57
CPCA61K35/57A61P1/00A61P1/04A61P9/10A61P11/00A61P13/02A61P13/10A61P15/00A61P15/10A61P21/02A61P25/00A61P25/08A61P25/18A61P25/22A61P25/24A61P25/28A61P29/00A61P43/00
Inventor BAIN, JERALDCHEN, HAOSADAVOY, JOELWEISSMAN, DAVID ARTHUR
Owner UNITED PARAGON ASSOCS
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