Methods and tools for detecting, diagnosing, predicting, prognosticating, or treating a neurobehavioral phenotype in a subject

a neurobehavioral and subject technology, applied in the field of methods and tools for detecting, diagnosing, predicting, prognosticating or treating a neurobehavioral phenotype in a subject, can solve the problems of large brain regions that cannot be fully functionally assessed, additional challenges, and large brain regions that cannot be functionally assessed, so as to minimize signal bleed across sulci, improve cortical folding management and alignment, and high flexibility
US20190102511A1Inactive Publication Date: 2019-04-04YALE UNIV +1
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
YALE UNIV
Publication Date
2019-04-04
Estimated Expiration
Not applicable · inactive patent

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Abstract

The present tools and methods for detecting, diagnosing, predicting, prognosticating, or treating a neurobehavioral phenotype in a subject. These tools and methods relates to a genotype and neurophenotype topography-based approach for analyzing brain neuroimaging and gene expression maps to identify drug targets associated with neurobehavioral phenotypes and, conversely, neurobehavioral phenotypes associated with potential drug targets, to develop rational design and application of pharmacological therapeutics for brain disorders, and to provide methods and tools for treatment of subjects in need of neurological therapy.
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Description

BACKGROUNDTechnical Field

[0001] The tools and methods described herein relate to a genotype and neurophenotype topography-based approach for analyzing brain neuroimaging and gene expression maps to identify drug targets associated with neurobehavioral phenotypes and, conversely, neurobehavioral phenotypes associated with potential drug targets, to develop rational design and application of pharmacological therapeutics for brain disorders. These tools and methods also provide for treatment of subjects in need of neurological therapy. Described herein is the selection, optimization, and ultimately targeting of therapeutics to specific neural circuits based on the bi-directional alignment of the neurobehavioral phenotypes and gene expression maps. This approach produces an actionable set of practical steps to aid therapeutic design and decision making based on the alignment or comparison of neuro-behavioral and transcriptomic data and the definition, and exploitation of, new neurophenot...

Claims

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