49 results about "Target engagement" patented technology

Biomarkers associated with inflammatory bowel disease (IBD) are provided, as well as methods of using such biomarkers for diagnosing, assessing and monitoring disease progression. The biomarkers may be measured at the protein level or the gene expression level Biomarkers may be tracked individually or in groups of two or more. The disclosed biomarkers may find particular utility in monitoring a course of therapy, such as treatment with an IL-23 antagonist. Changes in biomarker levels can also be used to confirm target engagement and therapeutic efficacy. Changes in biomarkers can also be used inform modification of a therapeutic regimen, for example to increase or decrease dosing of a therapeutic agent, such as an anti-IL-23 or anti-IL-23R anti-body.

A business method and a system that focuses on offering, coordinating, fulfilling and delivering an array of knowledge and productivity services that corporate customers require in today's context, the knowledge/business service combinations representing of mission-critical services with intellectual knowledge embodied, the fulfillment of which is done for a cluster of clients located in large commercial office buildings, government buildings or universities. The method of the invention provides for pooling of the requirements of various end users for scale-advantaged efficiencies in the processing and service delivery, and sharing such economies of scale generated with the building owners/property managers, who provide the venue from which to operate and enable such pooling to take place, and also with the tenant occupants/users, thus creating a market pull. The fulfillment of specific services is done by outsourcing to individual service providers who are established experts in their respective fields and who have virtual access to new business opportunities according to the method of the invention. The invention includes a market niche identification process and a networked processing system that delivers multiple-custom services to multiple-tenant users in multiple buildings/locations simultaneously, either directly and indirectly, and either with or without human intervention, and providing economies of scale and scope to all users, thus making it possible to offer such services at market-exchange pricing without the need for binding agreements. The processing system tracks utilization in a portfolio management style, by type of service as well as by user, for total spend-rates as well as by accrued savings, and for benchmarking purposes. The business method includes agents to facilitate targeted engagement of multi-tenant buildings from a location, size, networking, occupancy and potential point of view to build a network of multiple-buildings for even greater economies of scale and scope. The invention also includes applications related to wireless communications and choiceboards

A method, system, and computer program product of controlling driver interaction with an autonomous vehicle (AV) system for a vehicle are provided. In an embodiment, a signal indicating a present state of the driver is received. A signal indicating a past state of the driver is received. A present effectiveness of the driver is determined based on the received signals. A target level of engagement of the driver with the AV system is determined based on the present effectiveness of the driver.

A method for improving user interaction with a virtual environment includes measuring a first position of a user's gaze relative to the virtual environment, receiving a system engagement input, presenting a guidance cursor at the first position, receiving a target engagement input and decoupling the guidance cursor from the user's gaze, receiving a movement input, and translating the guidance cursor based on the movement input.

The present invention provides a MKV interceptor including multiple kill vehicles with autonomous management capability and kinematic reach to prosecute a large threat extent. Each KV can self-manage its own KV deployment and target engagement for a determined target volume assigned by a designated master KV. At least one KV is master capable of managing the post-separation of all of the KVs without requiring updates to the mission plan post-separation. The autonomous capability and increased kinematic reach provides for a more efficient use of boosters and more effective engagement of the threat.

Provided is a cowl-top cover mounting structure that: is capable of arranging a surface of a front glass and a surface of a cowl-top cover so as to be flush with each other; is capable of preventing unlocking of the clip member and the front glass when the cowl-top cover is engaged with the clip member. In present invention, a protrusion portion 21 of a clip member 20 is abutted against an end face 2e of a front glass lower end 2c, and the clip member 20 is fixed to a back face 2b of the front glass 2 via an adhesive agent 17. An engagement portion 13 that is formed in a tongue piece 12 of a cowl-top cover 10 is engaged with a target engagement portion 22 of the clip member 20, and the cowl-top cover 10 is mounted in a state in which a surface 11a of the cowl-top cover 10 and a surface 2a of the front glass 2 are arranged so as to be flush with each other. In addition, an engagement direction is defined as an engagement direction taken along a lengthwise direction oriented from a lower end to an upper end of the front glass.

The present invention relates to a single-target-specific fire fighting device for launching a liquid charge towards a localized target portion of a fire. The firefighting device is capable of highly precise target engagement at a single, localized area. In this manner, the fire fighting device can launch a single liquid charge effectively to a target location within a fire, such as the seat of a fire, in order to effectively extinguish the fire. The firefighting device includes at least a liquid charge having a flight integrity component, a barrel, a sighting structure coupled to the barrel, and a launching system for launching the liquid charge down the barrel at a target location.

A sighting and launching weapons system that incorporates the technologies of smart munitions and virtual reality (VR) simulation with precise target engagement capabilities; including targets that would normally be hidden from the shooter's field of view. Non-linear deployment of smart munitions to a precise target coordinate (via closed-loop navigation) allows for minimal collateral damage. Network link allows a plurality of operators to participate in coordinated target engagement in real time from one or more remote locations. The sighting and launching weapons system can be configured for a variety of uses including the deployment of weaponry or aid, and is capable of automatically identifying friendly targets from enemy targets.

The invention herein is directed to a selective Aβ oligomer immunoassay capable of reliably and sensitively detecting Aβ oligomers in a biological sample of a patient. In one embodiment the inventive assay uses a pair of anti-AP oligomer antibodies, 19.3 and 82E1, to detect and quantify Aβ oligomers in a cerebrospinal fluid (CSF) sample. The inventive assay can be used to differentiate Alzheimer's disease (AD) patients from non-AD patients and/or to stratify AD patients according to the severity of their disease. The inventive assay can also be used as a target engagement assay that can measure bound Aβ oligomers as a surrogate end-point for the assessment of therapeutic efficacy and/or target engagement.

A missile guidance system semi-physical simulation method of the invention includes the following steps: (1) a missile-target engagement mathematical model, a target simulator motor speed control model and a CCD camera motor speed control model are established in a host machine; (2) TCP/IP communication between the host machine and a target machine is established, and the TCP/IP communication is compiled to the target machine; (3) a CCD camera is powered on, and an image of an area where a target simulator is located is taken; (4) the image is transmitted to a target tracking experimental turntable control box; (5) a target is identified; (6) an operator uses a rocker to lock the target, and outputs the misalignment angle of a missile seeker to the target machine; (7) the process in whichthe missile seeker tracks the target is simulated; (8) the angular position and angular velocity information of the motor and the line-of-sight angular velocity are obtained; (9) key data in the simulation process is monitored in real time through the display of the target machine; and (10) the target machine feeds back the calculation result through a TCP/IP mode to the host machine for subsequent data analysis.

A method for ballistic target defense including identifying a launched ballistic target having a target launch point, a target launch direction, a target speed, and a target trajectory; launching a target interceptor in a launch direction that is generally the same as the target launch direction and with a speed that is less than the target speed; providing the interceptor with an approximate target intercept trajectory, and accelerating the interceptor at an approximate point of intercept to substantially match the target trajectory. During a relatively long target engagement time, the interceptor has approximately a zero net relative velocity with respect to the target. The interceptor will have a speed change capability sufficient to maneuver the interceptor around and/or in a target object cloud, providing the interceptor with the ability to inspect an object of the object cloud, capture an object of the object cloud, nondestructively engage in object of the object cloud, and/or destructively engage in object of the object cloud. Embodiments are also directed to a ballistic target defense system and a ballistic target interceptor.

Systems and methods for contiguously and accurately updating target object information during an entire target engagement period are provided. The target tracking system includes a database for storing starfield information, an optical beam source configured to illuminate one or more optical beam pulses, first and second camera systems, and a processor. The processor instructs the first camera system to track the object based on recordation of the tracked object, instructs the second camera system to stabilize the tracking image based on the instructions sent to the first camera system, and determines inertial reference information of the tracked object based on the stabilized image and starfield information associated with the stabilized image.

A card edge connector includes a connector including a target engagement part, a substrate that can be inserted into and removed from the connector, a fixing part fixed to the substrate, and a lock that secures the substrate to the connector. The lock includes a shaft fixed to the fixing part and configured to slide in the direction of insertion and removal of the substrate and rotate around an axis, an urging part that exerts force on the shaft and biasing the shaft toward the direction of the substrate, and an engagement part provided on the shaft, configured to engage the target engagement part.

A knee-protection airbag device includes: an airbag being inflatable when an inflating gas flows thereinto; and a casing receiving the airbag in a folded state, wherein: the casing includes an attachment seat portion attached to an attachment bracket disposed to extend from a body; the casing includes an engagement portion engaging with a target engagement portion formed at the attachment bracket; when the engagement portion engages with the target engagement portion while the suspension portion is suspended on the target suspension portion, the airbag assembly is suppressed from rotating backward and deviating in a horizontal direction; and when the attachment seat portion contacts a rear face of a fixation seat portion, the attachment hole formed at the attachment seat portion matches an attachment hole formed at the fixation seat portion.

An AESA system comprises a plurality of arrays, each comprising a plurality of radiating elements, each array configured for placement on a forward-facing surface of a different one of a plurality of aerodynamic control surfaces on an interceptor. A plurality of RF transmissive radome elements, each having an aerodynamic shape complementary to the aerodynamic control surface, are placed over one of the arrays. Control circuitry configures the arrays, independently or in concert, for RF target engagement and communication. Additional arrays may be positioned on side or aft-facing surfaces of the aerodynamic control surfaces for RF communication. The AESA system may be paired with an ER system for dual-mode operation.

A system, called the Laser Aim Scoring System, and method for automatically scoring gunner training sessions for simulated laser-guided missile, target engagements using the laser designator without the need for training or tactical rounds are disclosed. In the disclosed invention, a pop-up target and its surrounds are separately monitored for radiations at the laser designator frequency. “Hit” or “Miss” scoring is based on detection of the laser radiation at the laser designator frequency illuminating the appropriate region around or on the target at the appropriate time with respect to a simulated missile launch signal at the start of the training engagement, in accordance with the engagement profile programmed into the scoring computer prior to the start of training. The laser aim scoring system send a signal to lower the pop-up target in response to a “Hit” score, and if desired by the user, also sends a signal to initiate smoke and flash signals from a Hoffman Kill Simulator interfaced with the system. The disclosed invention also sends the appropriate signals at the end of the engagement to reset the target in the upright position so that it is ready for the next engagement. The disclosed invention includes subsystems for transmitting data, video imagery, and control signals between the portion of the system at the target location and the portion of the system at the control tower.

The present invention provides a method for diagnosing or determining the risk of developing Alzheimer's disease and for treating Alzheimer's disease with S-equol. An aspect of the present invention includes the use of a direct mitochondrial target engagement biomarker to diagnose or assess the risk of developing Alzheimer's disease. Another aspect of the present invention includes the use of a pharmaceutically effective amount of S-equol to treat or prevent Alzheimer's disease in a subject diagnosed with or determined to be at risk of developing Alzheimer's disease.

The invention relates to biomarkers associated with LSD1 inhibitors and uses thereof to assess target engagement and to follow patient response to treatment. The invention further relates to novel therapeutic uses for LSD1 inhibitors based on said biomarkers.

The invention relates to a method for actuating a multi-plate clutch 1 between an input shaft 2 and an output shaft 3 for the switchable transmission of torques, wherein, when there is a torque requirement 4 and a subsequent engagement of the multi-plate clutch 1, at least the following steps are carried out: a) determining a target engagement force 6, effective in an axial direction 5, of the multi-plate clutch 1 for the transmission of a target torque 9 to the output shaft 3; b) determining and setting a limit engagement force 7 which is smaller than the target engagement force 6; and c) setting the target engagement force 6 in a delayed manner. The limitation of the target engagement force 6 to the limit engagement force 7 means that a transmission of an actual torque 8 is realised, wherein a maximum actual torque 8 transmitted when the multi-plate clutch 1 is engaged exceeds a target torque 9 to be transmitted by at most 5%.

An ECU executes a program including the steps of: if downshift from a fifth gear implemented when a brake and a clutch both engage to a second gear implemented when a clutch and a brake both engage is done, or downshift from a sixth gear implemented when the brake and the clutch both engage to a third gear implemented when the clutch and the brake both engage is done, disengaging a frictional engagement element other than the clutch, i.e., the brake or the brake; and decreasing an engagement pressure that is applied to the clutch to a reference value of target engagement pressure.