The invention discloses a safety shut-off valve. The safety shut-off valve comprises a valve body, an upper valve body and a shut-off mechanism. The valve body is provided with a first channel and a second channel, the upper valve body is connected with the upper end of the valve body through a screw and used for sealing the valve body, and the shut-off mechanism is arranged in the middle of the valve body and used for connecting or disconnecting the first channel and the second channel. The safety shut-off valve is characterized in that the shut-off mechanism comprises a shut-off part and a cam connecting device which are separated from each other; the valve body is integrally formed by forged steel in a turn milling mode. The independent cam connecting device is adopted, so that separated repair is facilitated, and the situation that the shut-off valve cannot work normally due to maintenance assembly errors is avoided; the internal structure of the valve body is simple, the forged steel integration valve body is adopted, the internal organizational structure of the valve body is improved, grains are refined, the mechanical properties, such as shock resistance, plasticity and toughness, of the forged steel integration valve body are superior to those of a cast steel valve body, and the safety performance of the valve is improved.