Methods of treating chronic disorders with complement inhibitors

a technology of complement inhibitors and chronic disorders, applied in the field of chronic disorders with complement inhibitors, can solve the problems of 300 million individuals worldwide, morbidity and mortality whose incidence is increasing worldwide, asthma is also a significant global health problem, etc., and achieves the effects of inhibiting plasma complement activation capacity, prolonging the effect, and reducing one or more manifestations
US20190192617A1Inactive Publication Date: 2019-06-27APELLIS PHARMA
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Patent Information

Authority / Receiving Office
US ยท United States
Patent Type
Applications(United States)
Current Assignee / Owner
APELLIS PHARMA
Publication Date
2019-06-27
Estimated Expiration
Not applicable ยท inactive patent

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Abstract

In some aspects, the invention provides methods of treating a subject in need of treatment for a chronic complement-mediated disorder. In some aspects, the invention provides methods of treating a subject in need of treatment for a Th17-associated disorder. In some aspects, the invention provides methods of treating a subject in need of treatment for a chronic respiratory system disorder. In some aspects, the invention provides methods of administering a complement inhibitor to a subject. In some embodiments, a method of treating a subject comprises administering multiple doses of a complement inhibitor to the subject according to a dosing schedule that leverages the prolonged effect of complement inhibition in chronic respiratory disorders. In some embodiments, a subject has chronic obstructive pulmonary disease. In some embodiments, a subject has asthma.
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Description

CROSS-REFERENCE TO RELATED APPLICATIONS

[0001] The present application claims priority to U.S. provisional patent application No. 61 / 499,895, filed Jun. 22, 2011, the entire contents of which are hereby incorporated by reference.BACKGROUND OF THE INVENTION

[0002] Chronic disorders of the respiratory system are significant causes of morbidity and mortality whose incidence is increasing worldwide. According to World Health Organization estimates, about 80 million people have moderate to severe chronic obstructive lung disease (COPD), and more than 3 million people died of COPD in 2005 (หœ5% of all deaths globally). COPD was the fifth leading cause of death in 2002, and estimates suggest that it will be the third leading cause of death worldwide in 2030 unless major risk factors, particularly tobacco use, can be successfully curbed. Asthma is also a significant global health problem, affecting an estimated 300 million individuals worldwide. Both asthma and COPD can have debilitating effects...

Claims

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