Combination therapy for the treatment of autoimmune diseases
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[0062]As a model for diabetes type 1 the RIP-LCMV mouse was used. Transgenic RIP-LCMV-GP mice express glycoprotein (GP) of the Lymphocytic Choriomeningitis Virus (LCMV) under the control of the rat insulin promoter (RIP). The promoter allows for the specific expression in the beta cells of the Langerhans islets of the pancreas (Oldstone MBA et al, Cell, 1991). The transgenic mice therefore express the viral GP and tolerate the protein as “self”. However, infection with the LCMV induces a LCMV specific immune response that not only targets the virus but also the beta cells expressing the viral GP protein. Usually, the RIP-LCMV-GP mice develop type 1 diabetes after 10 to 14 days of the infection.
[0063]For the experiments, the above mice when diabetic were treated for three days with 3 μg / day anti-CD3 antibody (Aimenian hamster anti-mouse CD3e IgG F(ab′), clone 145-2C11; Chatenoud L, et al. 1997, J Immunol.). Subsequently, the mice were treated three times a week with 100 μg a...
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