Selective cyclic peptides with melanocortin-4 receptor (MC4-R) agonist activity
Patent Information
- Authority / Receiving Office
- US · United States
- Patent Type
- Patents(United States)
- Current Assignee / Owner
- F HOFFMANN LA ROCHE & CO AG
- Publication Date
- 2006-05-16
- Estimated Expiration
- Not applicable · inactive patent
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Abstract
Description
PRIORITY TO PROVISIONAL APPLICATION(S) UNDER 35 U.S.C. § 119(E)
[0001] This application claims priority under 35 U.S.C. § 19(e) of provisional application(s) Ser. No. 60 / 229,184, filed Aug. 30, 2000.BACKGROUND OF THE INVENTION
[0002] Obesity is widely recognized as a serious health problem for the developed countries, and has reached epidemic status in the United States. More than 50% of the U.S. population is considered overweight, with >25% diagnosed as clinically obese and at considerable risk for heart disease, non-insulin dependent diabetes mellitus (NIDDM), hypertension, and certain cancers. This epidemic presents a significant burden on the health care system as projected obesity treatment costs of more than $70 billion annually are expected in the U.S. alone. Strategies for treating obesity include reducing food intake or enhancing the expenditure of energy.
[0003] It has been demonstrated that, when injected into the third ventricle of the brain or intraperitoneally, a cyclic ...