Streamline-based microfluidic device

a microfluidic device and streamline technology, applied in the direction of positive displacement liquid engine, laboratory glassware, instruments, etc., can solve the problems of inability to separate all, pore clogging or membrane fouling may be an issue, and the separation becomes difficul

Active Publication Date: 2013-01-15
IRIS INT +1
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, when the particle size is much smaller or when the difference in particle size is smaller, separation becomes difficult.
Pore clogging or membrane fouling may be an issue.
Such procedures are typically not able to separate all of the white blood cells from the platelets and the forces involved in separation of the cells can damage the final product.
Cell labeling-based separation techniques are expensive, inconvenient and in most cases, labeled cells cannot be infused in patients and the harsh washing conditions necessary to remove the label can damage the cells.
Passive matrix-based separation techniques are not sufficiently selective or adaptive for separation of specific cell types.
Similarly, column chromatography and magnetic bead adsorption techniques cannot separate cell subtypes quickly and cheaply.

Method used

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Embodiment Construction

[0023]The present invention provides a novel streamline-based microfluidic device and a method of using such a device for continuous separation of particles of various sizes. The device is especially useful for the separation of erythrocytes from leukocytes in the blood. In certain instances, the present invention provides a system, which does not require moving parts, and thus it is desirable for integration with other kinds of micro unit operation for other treatment, analysis and utilization. The present invention demonstrates a high separation efficiency, an ease of operation, capability of simultaneous particle concentration and size dependent separation and elimination of channel clogging. Advantageously, the microfluidic device can have a tailored design with a tunable capability to allow easy and accurate manipulation of particles of various sizes found in biological, ecological and industrial environments, especially in the separation of particles and cells in the blood to ...

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Abstract

The present invention provides a streamline-based device and a method for using the device for continuous separation of particles including cells in biological fluids. The device includes a main microchannel and an array of side microchannels disposed on a substrate. The main microchannel has a plurality of stagnation points with a predetermined geometric design, for example, each of the stagnation points has a predetermined distance from the upstream edge of each of the side microchannels. The particles are separated and collected in the side microchannels.

Description

CROSS-REFERENCES TO RELATED APPLICATIONS[0001]This application claims priority to U.S. Provisional Patent Application No. 60 / 673,572, filed Apr. 21, 2005, which is hereby incorporated by reference in its entirety for all purposes.STATEMENT AS TO RIGHTS TO INVENTIONS MADE UNDER FEDERALLY SPONSORED RESEARCH OR DEVELOPMENT[0002]A portion of the present invention was made under federally sponsored research and development under NASA through the National Space Biomedical Research Institute (NSBRI). The co-operative agreement number is NCC 9-58-317. The Government may have rights in certain aspects of this invention.BACKGROUND OF THE INVENTION[0003]Separation of particles based on size is one of the essential components in biochemical analysis, environmental assays, and industrial and biomedical applications. Filtration is one of the most frequently used techniques to separate particles. A mechanical filter can be used to remove, filter, or collect particles. This filtering and collection...

Claims

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Application Information

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Patent Type & Authority Patents(United States)
IPC IPC(8): B01L3/00G01N1/00
CPCB01L3/502761B01L3/502746B01L2200/0636Y10T436/2575B01L2400/0487B01L2400/0688B01L2200/0652
Inventor TAI, YU-CHONGZHENG, SIYANGKASDAN, HARVEY
Owner IRIS INT
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