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Compositions comprising rutin useful for the treatment of tumors resistant to chemotherapy

a technology of chemotherapy and compositions, which is applied in the direction of biocide, plant growth regulators, plant ingredients, etc., can solve the problems of increasing the frequency of multiple resistance, increasing the number of times of tumor cells resistant to chemotherapy, and a huge problem of tumor cells to chemotherapeutic treatmen

Inactive Publication Date: 2017-09-12
PROBIOTICAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Benefits of technology

[0002]The present invention relates to the use of rutin for increasing the effectiveness of chemotherapeutic treatments used in human and veterinary medicine for the treatment of tumors, in particular in case of resistance to chemotherapeutics currently in use.

Problems solved by technology

Currently, the resistance of tumor cells to chemotherapeutic treatment represents a huge problem subject to a continuous development.
An even more serious problem is represented by multiple chemoresistance, i.e. the occurrence, after a treatment with a given chemotherapeutic agent, to other chemotherapeutics.
An approach aiming at overcoming the problem of chemoresistance is the combination therapy with different types of chemotherapeutics: however, also in this case the outcomes are not satisfactory and lead to an alarmingly, increasingly frequent multiple resistance to various chemotherapeutics.
Despite the continuous research and development of new drugs, to be used also in combination, the problem of chemoresistance remains and seems to be unavoidable due to the malleable nature of cancer cells [Fojo T. and Bates S., Cancer Discov; 3(1); 20-3, 2012].

Method used

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  • Compositions comprising rutin useful for the treatment of tumors resistant to chemotherapy

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example 2

on of an Alcoholic Extract from Dry Plants

[0055]An amount of dry plants of 370 to 450 grams is used for 1200 ml of hydroalcoholic solution (40% to 90% ethanol). The whole is left to “rest” for about two weeks. At the end of the impregnation / dyeing of the solvent, the liquid part is removed, the vegetable part is pressed, the liquids are gathered and then filtered.

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Abstract

Use of rutin for increasing the effectiveness of chemotherapeutic treatments used in human and veterinary medicine for the treatment of tumors is described, in particular in case of resistance to chemotherapeutics currently in use.

Description

CROSS REFERENCE TO RELATED APPLICATIONS[0001]The present application is the US national stage entry of International Patent Application No. PCT / IB2014 / 063187 filed internationally on Jul. 17, 2014, which claims priority to Italian Patent Application No. MI12013A001495 filed on Sep. 10, 2013.SUMMARY OF THE INVENTION[0002]The present invention relates to the use of rutin for increasing the effectiveness of chemotherapeutic treatments used in human and veterinary medicine for the treatment of tumors, in particular in case of resistance to chemotherapeutics currently in use.TECHNICAL BACKGROUND[0003]Currently, the resistance of tumor cells to chemotherapeutic treatment represents a huge problem subject to a continuous development. Drug resistance arises both in solid tumors and in lymphatic system tumors and can occur since the onset of a treatment or afterwards, after an initial positive response to the treatment. For instance, chemoresistance very often arises in the course of the tre...

Claims

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Application Information

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Patent Type & Authority Patents(United States)
IPC IPC(8): A01N43/04A61K31/34A61K31/337A61K31/365A61K31/4745A61K31/7048A61K31/664A61K31/70A61K45/06A61K36/66A61K36/29A61K36/28A61K31/704A61K31/675A61K31/555A61K31/519A61K31/513A61K31/136A61K31/4375A61K31/4741
CPCA61K31/7048A61K31/136A61K31/337A61K31/34A61K31/365A61K31/4375A61K31/4741A61K31/4745A61K31/513A61K31/519A61K31/555A61K31/664A61K31/675A61K31/704A61K36/28A61K36/29A61K36/66A61K45/06A61K2300/00A61P35/00A61P43/00
Inventor FRASCINI, FRANCOIRITI, MARCELLOMAESTRI, PAOLORIMONDINI, LIACATALANO, ENRICOMEGNA, SAVERIO
Owner PROBIOTICAL
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