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Dialysate filter including an asymmetric microporous, hollow fiber membrane incorporating a polyimide

a polyimide and filter technology, applied in the field of dialysate filters, can solve the problems of restricted dialysate flow, increased temperature and leakage, etc., and achieve the effects of quick and easy installation, effective monitoring of filtering, and increased temperatur

Inactive Publication Date: 2000-10-17
MEDIVATORS INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

It is an object of the present invention to provide a dialysate filter which solves the problems outlined above that inhibited regular use of a dialysate filter, including difficult to use, expense and safety risks. The dialysate filter of the present invention enables the practitioner to quickly and easily install a dialysate filter outside the housing of a dialysis apparatus and thereby effectively monitor the filter and prevent dialysis machine complications. Dialysis machine complications include restricted dialysate flow, increased temperature and leaks. The dialysate filter of the present invention works well with a variety of dialysis machines and tolerates a wide variety of disinfecting chemicals without loss of integrity.

Problems solved by technology

Dialysis machine complications include restricted dialysate flow, increased temperature and leaks.

Method used

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  • Dialysate filter including an asymmetric microporous, hollow fiber membrane incorporating a polyimide
  • Dialysate filter including an asymmetric microporous, hollow fiber membrane incorporating a polyimide
  • Dialysate filter including an asymmetric microporous, hollow fiber membrane incorporating a polyimide

Examples

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examples

The following specific examples which contain the best mode, can be used to further illustrate the invention. These examples are merely illustrative of the invention and do not limit its scope.

examples 1-7

characterize and describe how to prepare the polyimide fibers according to one preferred embodiment of the present invention. Examples 8-29 describe the preparation, testing, cleaning and use of the filters of the present invention.

example 1

A polymeric dope solution was formed by dissolving 17.5 wt. % of P84 in dimethylformamide. The material was filtered and then pumped to a tube-in-orifice spinerette at a rate of 4.50 mL / min and at a temperature of 24.degree. C. Simultaneously, a precipitating solution consisting of 80 wt. % dimethylformamide and 20 wt. % reverse osmosis deionized water was mixed, filtered and delivered to the spinerette at a temperature of 24.degree. C. and a rate of 2.75 mL / min.

The polymeric dope solution was delivered through the outer, annular orifice of the spinerette, which orifice had an outside dimension of about 0.022 to 0.025 inches (about 560 .mu.m) and an inside dimension of about 0.010 inches (about 254 .mu.m). The precipitating solution was delivered through a tube-in-orifice within the annular orifice, which tube-in-orifice had an inside diameter of about 0.005 inches (about 127 .mu.m). The spinerette head was maintained at 24.degree. C. The spinerette discharged the polymeric solution...

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Abstract

A dialysate filter including asymmetric, microporous, hollow fiber membranes incorporating a polyimide. The dialysate filter connects to the dialysis machine immediately before the dialyzer ensuring complete filtration of the dialysate, easy visual inspection, quick installation and removal, and easy disinfection of the filter.

Description

BACKGROUND OF THE INVENTION1. Field of the InventionThis invention relates generally to a dialysate filter which is easy to install, durable and cost effective. In particular, the invention relates to a dialysate filter which removes bacteria and endotoxins from a dialysate stream before it enters an artificial kidney. Still further, the dialysate filter of the present invention includes improved asymmetrical, microporous, hollow fibers incorporating a polyimide.2. Description of the Related ArtA dialysate filter is a device which can be used in-line, between a dialysis apparatus and an artificial kidney (dialyzer) during hemodialysis treatments, to remove bacteria and endotoxins from the dialysate stream. Endotoxins are potentially lethal lipopolysaccharide (LPS) molecules which are released when gram-negative bacteria disintegrate or are destroyed.Endotoxins can cause Pyrogenic Reactions (PRs) in dialysis patients either directly by passing through an artificial kidney membrane in...

Claims

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Application Information

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Patent Type & Authority Patents(United States)
IPC IPC(8): B01D61/24B01D61/30B01D71/00B01D69/00B01D69/08B01D69/02B01D71/64
CPCB01D61/30B01D71/64B01D69/08B01D69/02B01D63/02
Inventor CARLSEN, DANIEL B.ANDRUS, ROBERT G.HALL, II, ROBERT T.
Owner MEDIVATORS INC
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