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Injectable microfoam containing a sclerosing agent

a technology of sclerosing agent and injectable microfoam, which is applied in the direction of aerosol delivery, prosthesis, drug composition, etc., can solve the problems of ineffective process in these vessels, limited to short varicose segments, and inability to apply sclerotherapy to large varicose trunci

Inactive Publication Date: 2005-12-13
BTG INT LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

"The present invention relates to a technique for treating large varices (blood vessels) called sclerosis. The invention involves injecting a microfoam made of physiological serum and a sclerosing agent into the vein to cause displacement of the blood and sclerosis (the hardening of the vein). The advantages of this technique include the ability to know the concentration of the sclerosing agent in the vein, the guarantee of homogenous distribution of the sclerosis agent, and the control of the time in which it is in contact with the vein walls. The invention can be carried out using existing methods and equipment."

Problems solved by technology

The results are uncertain (due to overdose or underdose) and limited to short varicose segments.
Sclerosis and surgery complement each other at this time, but sclerotherapy continues without being able to be applied to large varicose trunci.
In thick varices, upon injecting air, the described phenomenon of displacement of the blood by the injected air does not take place, but rather this forms a bubble inside the vein that makes the process ineffective in these vessels.
The process turns out to be rather useless due to the large-sized bubbles formed and dangerous due to the collateral effects of the atmospheric nitrogen, not very soluble in blood.
Both methods had very little practical repercussion as they were used only in small varices.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0022]The preparation of the sclerosing microfoam is done by mixing in a sterile, hermetic container and connected if desired to a bottle under oxygen pressure, mixture of oxygen and carbon dioxide or other physiological gassesgases; mechanical beating is carried out by means of a micromotor that makes an écouvillon submerged in the sclerosing solution to be foamed turn.

[0023]Beating between 8,000 and 15,000 rpm, for a time between 60 and 120 seconds, the microfoam is achieved.

[0024]This is introduced into any container that can be used for subsequent storage and later injection into the veins to be sclerosed.

[0025]In the event that the sclerosing agent does not have a foaming capacity Polysorbate 20, Polysorbate 80, Polygeline or any other substance with a foaming capacity accepted as inert for intravenous use is added to it.

example 2

[0026]The sclerosing agent is introduced into a hermetic, pressurized and sterile container and by stirring the solution the microfoam is achieved, with a outlet from the container for its subsequent use.

[0027]The invention can also embrace prepared or extemporaneously prepared injectable microfoam for therapeutic uses characterized in that the microfoam is prepared with any sclerosing substance. In one embodiment, the sclerosing substanc in the injectable microfoam is polidocanol. In another embodiment, it is sodium tetradecyl sulfate. In a further embodiment, it is a hypertonic glucostated or glucosaline solution. In still another embodiment, the sclerosing substance can be chromated glycerol. The sclerosing substance in another embodiment is ethanolamine oleate. Another embodiment could envisage sodium morrhuate as the sclerosing substance. Still another, envisages any iodated solution.

[0028]The present invention also uses the inventive microfoam in phlebology. The sclerosing sub...

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Abstract

Injectable microfoam for sclerotcraphy. The sclerotherapy of varices is based on the injection of liquid substances capable of suppressing them. The present invention relates to the preparation of sclerosing substances in the form of a microfoam. The microfoam is prepared with sclerosing agents, and is then injected in the vein to be treated, so that the microfoam displaces the blood contained in the vein and provides for the contact of the sclerosing agent with the vascular endothelium, with a predetermined known concentration and during a controllable time.

Description

[0001]This is a continuation of international application Serial No. PCT / ES94 / 00064, filed Jun. 21, 1994.PRIOR ART[0002]SchlerosisSclerosis of varices is based on injecting liquid substances in them, which causing a localized inflammatory reaction propitiates the elimination of these abnormal veins.[0003]Upon injecting a sclerosing agent, a mixture thereof with the blood contained in the vein is produced and diluted in an unknown proportion. The results are uncertain (due to overdose or underdose) and limited to short varicose segments. As the size of the varices to be injected decreases, the lesser this dilution is and the results that are obtained are more foreseeable. Nowadays, sclerosis is a technique chosen in cases of small and medium-sized varices. Surgery is used for those varices with a diameter equal to larger than 7 mm.[0004]Sclerosis and surgery complement each other at this time, but sclerotherapy continues without being able to be applied to large varicose trunci.[0005...

Claims

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Application Information

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Patent Type & Authority Patents(United States)
IPC IPC(8): A61F2/01A61K9/12
CPCA61K9/122Y10S424/07A61K31/08A61P9/14
Inventor GARRIDO, JUAN CABRERAGARCIA-OLMEDO, JUAN CABRERA
Owner BTG INT LTD
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