The invention mainly relates to the technical field of planting, and discloses a handling method of accelerating germination of a seed of fructus lycii. The processing method comprises the steps of seed soaking, seed drying, seed dressing and germination acceleration, and soil preparation and seed sowing. According to the handling method of accelerating germination of seed of fructus lycii, the method is simple, the bud ratio is 98%, time for germination is shortened to 4-5 days after the sowing, plant efficiency is obviously improved, and economic income is improved by 16.2%; the seed of fructus lycii is subjected to soaking through an amitriptyline solution, nutritional contents are provided, not only anti-microbial and insect killing effects are achieved, seed coat softening is also promoted, entering of nutritients and moisture are accelerated, and seed germination is promoted; after the seed is subjected to drying and surface skin moisture reducing, seed germ vigour is promoted at high temperature, stress resistance is improved, and germination rate is improved; bactericide is added into the dried seed, wherein the bactericide is extracted from pure plants, and can the bactericide can not only prevent bacteria and kill insects, but can also provide nutrients necessary to the germination of the germ, and thus the germination of the seed is accelerated.