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Coating agent for treating insomnia and its usage

The technology of a coating agent and cetyl alcohol, which is applied in the field of coating agents for treating insomnia, achieves the effect of simple preparation and use and remarkable curative effect

Active Publication Date: 2008-07-16
袁重华
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It should be said that so far there is no hypnotics that fully meet these conditions, so it is the goal of the present invention to develop ideal sedative-hypnotic drugs and preparations that meet the above conditions as much as possible.

Method used

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  • Coating agent for treating insomnia and its usage
  • Coating agent for treating insomnia and its usage
  • Coating agent for treating insomnia and its usage

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0025] The coating agent of the present invention can be prepared by a conventional method for preparing a coating agent.

[0026] Usage: Apply on the skin surface like a cream, and apply it once a day.

Embodiment 1

[0028] compound 15, oxazepam, oxazepam 25

[0029] Octadecanoic acid 2

[0030] cetyl alcohol 1

[0031] Anhydrous lanolin 1

[0032] white oil 1

[0033] 1-n-dodecylazepan-2-one 3

[0034] Isopropyl myristate 2

[0035] Siben-60 1

[0036] Triethanolamine 1

[0037] Propylene Glycol 2

[0038] Kayson CG 0.05

[0039] margin is H 2 O, make up to 100.

[0040] Trial effect observation:

[0041] 49.8% of patients fell asleep within 40 minutes after applying the prescribed amount of medicine; 53.1% of patients did not wake up at night, and 56.1% had no dreams; 50.1% fell asleep soon after waking up (toilet); the sleep time lasted more than 6 hours Accounted for 62.8%, 75.8% of the patients woke up the next morning with clear mind and no discomfort; 80.3% were satisfied with this. The total effective rate is 75%

Embodiment 2

[0043] cetyl alcohol 3

[0044] Lanolin 2

[0045] lanolin 2

[0046] white oil 3

[0047] mink oil 1

[0048] 1-n-dodecylazepan-2-one 3

[0049] Glyceryl Tristearate 3

[0050] Siben-60 2

[0051] Tween-60 1

[0052] Glycerin 3

[0053] Hyaluronic Acid 0.5

[0054] Kayson CG 0.05

[0055] compound 1, zopiclone, zopiclone 1

[0056] Compound 7, alprazolam, alprazolam 0.05

[0057] margin is H 2 O, make up to 100.

[0058] Trial effect observation:

[0059] 70.6% of the patients fell asleep within 30 minutes after applying the medicine according to the dose; 65.1% of the patients did not wake up after falling asleep, and 72.1% of the patients did not dream; 80.5% of the patients continued to sleep for more than 6 hours, and 90.6% of the patients had no drowsiness after waking up And clear-headed, no discomfort; 96% are quite satisfied with the improvement of their sleep. The total effective rate is 84.3%.

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Abstract

Coating agent for treating insomnia and its usage for treating asomnia, wherein the coating agent comprises one or more active ingredients as well as auxiliary substance.

Description

technical field [0001] The invention relates to a coating agent and its application for treating insomnia, in particular to a coating agent for treating insomnia and its application for treating insomnia. Background technique [0002] The most basic definition of insomnia is sleep disturbance and refers to the frequent inability to get normal sleep. Researchers believe that insomnia is insufficient sleep, or sleep is not deep, not familiar, generally presents three characteristics of initial insomnia, intermittent insomnia and terminal insomnia. Occasional insomnia doesn't matter much, and only those who can't sleep for a long time are considered to have insomnia. The incidence of insomnia is very high. According to foreign data surveys, the incidence of insomnia in the American population is 32% to 35%, and that in Japan is 20%. Although there is no such survey in China at present, according to the observation of clinicians, there are quite a few patients with insomnia in...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/5517A61K31/5513A61P25/20
Inventor 袁重华
Owner 袁重华