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Liquid wound-dressing with functions of promoting heal of wound and bacterial-resisting

A wound dressing and liquid technology, applied in medical science, bandages, etc., to reduce infection, cool to the touch, and promote wound healing

Inactive Publication Date: 2009-03-25
JIANGSU 139 MEDICAL DEVICES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, there is no public literature at home and abroad to report that sodium hyaluronate is the main ingredient, and nano-silver is added to make a gel as a liquid wound dressing.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Take 4 grams of sodium hyaluronate, add it to 90 grams of distilled water while stirring rapidly, stir until the sodium hyaluronate is completely dissolved (preparation for current use), then add 4 grams of nano-silver aqueous solution with a concentration of 10000ppm (nano-silver average particle The diameter is about 50nm), supplemented with distilled water to 100 grams, stirred to form a gel, filled, and sterilized by irradiation.

Embodiment 2

[0031] Take 2.5 grams of sodium hyaluronate, add it to 50 grams of distilled water while stirring rapidly, stir until the sodium hyaluronate is completely dissolved (preparation for current use), and add 0.5 grams of carbomer (940) to 40 grams while stirring gram of distilled water until the carbomer is completely swollen, then add 0.6 gram of triethanolamine and stir evenly, mix with the prepared sodium hyaluronate solution (measured pH is 6.5), then add 3 gram of nano silver (10000ppm, nano silver average The particle size is about 20nm), supplemented with distilled water to 100 grams, stirred evenly to form a gel, filled, and sterilized by irradiation.

Embodiment 3

[0033] Take 2.5 grams of sodium hyaluronate, add it into 40 grams (about 70°C) of clean deionized water while stirring, stir until the sodium hyaluronate is completely dissolved (preparation for current use), and take another 1.5 grams of modified chitosan while stirring Add 40 grams of distilled water until chitosan is completely dissolved, then add 5 grams of glycerol and stir evenly, mix with the prepared sodium hyaluronate solution, then add 2 grams of nano silver (10000ppm, the average particle size of nano silver 10nm or so), supplemented with distilled water to 100 grams, stirred to form a gel, filled, and sterilized by irradiation.

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Abstract

The present invention provides a liquid wound dressing with the functions of promoting wound healing and resisting bacteria. Said liquid wound dressing contains 0.5-5.0 wt% of hyaluronic acid and its derivative and 0.0005-0.04 wt% of gel of nano silver. It also can contain water-soluble high-molecule and humectant. Said invention also provides its concrete application method.

Description

technical field [0001] The invention relates to a pharmaceutical preparation, in particular to a composition of a liquid wound dressing and a preparation method thereof. Background technique [0002] The development of new medical dressings originated from the discovery of wet therapy. Hydrogel is one of them. It is used as a carrier of drugs and used in the repair of body tissues. It is divided into two types: thin film and amorphous. Amorphous hydrogel is a paste-like product, generally a fluid with a very high water content formed by dispersing water-soluble polymers in water and preservatives. The main function of this type of product is to provide moisture to the wound. A moist environment promotes wound healing. [0003] Hyaluronic acid is a self-synthesized molecule that exists in various parts of the body, and plays a variety of important physiological functions such as tissue hydration and proteoglycan organization in human skin. When the tissue is traumatized, it...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L26/00
Inventor 赵成如郈秀菊
Owner JIANGSU 139 MEDICAL DEVICES
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