Wasp antibiotic peptide and preparing method and use thereof

An antibacterial peptide, wasp technology, applied in the field of biomedicine, can solve problems such as side effects and adverse reactions
CN100475840CInactive Publication Date: 2009-04-08KUNMING INST OF ZOOLOGY CHINESE ACAD OF SCI
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
KUNMING INST OF ZOOLOGY CHINESE ACAD OF SCI
Publication Date
2009-04-08
Estimated Expiration
Not applicable · inactive patent

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Abstract

The present invention belongs to the field of biomedicine technology. Wasp antibiotic peptide is a kind of single-stranded polypeptide separated from wasp venom and with molecular weight of 1316.6 dalton, isoelectric point of 8.59, and polypeptide whole sequence of NH2-IDWKGIAAMAKI-COOH. It is prepared through electrically stimulating wasp to collecting wasp venom, centrifuging to eliminate precipitate, freeze drying, chromatographic separation and purification in gel column, ion exchange column and reverse high pressure liquid phase chromatography. The wasp antibiotic peptide has powerful activity of inhibiting bacteria, fungi, viruses and tumor cell growth and the advantages of no hemolysis activity, etc. and may be used in preparing medicine for treating pathogeneic microbial infection disease and tumor.
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Description

Technical field:

[0001] The invention relates to a vespa antibacterial peptide and its preparation method and application, belonging to the technical field of biomedicine. Background technique:

[0002] Since the discovery of penicillin, people are no longer helpless against various diseases caused by pathogenic microorganism infection, and thus developed a large number of β-lactam antibiotics, which have made great contributions to the protection of human health. However, with the widespread use of the above-mentioned "traditional antibiotics", many new problems continue to arise. Such as long-term use leads to the generation of drug-resistant strains. Sometimes it even develops to the point that some pathogenic bacteria infections have no drugs for clinical treatment. Therefore, the development of a new generation of antibacterial agents has become a top priority. Recent studies have found that polypeptide antibiotics have broad-spectrum antibacterial activity, and at t...

Claims

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