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Orally disintegrating tablet of coenzyme Q10 and preparation method thereof

An orally disintegrating tablet and coenzyme technology, which is applied in the direction of pharmaceutical formulas, medical preparations with no active ingredients, and medical preparations containing active ingredients. The low melting point of Q10 achieves the effects of easy taking and carrying, fast onset of action, and short disintegration time limit

Inactive Publication Date: 2009-05-20
重庆市力扬医药开发有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] Due to the low melting point of coenzyme Q10 (48~52°C), after granulation, if the drying temperature is higher than 48°C, coenzyme Q10 will melt, so it can only be dried at low temperature
However, if it is dried in an ordinary oven, the drying time will be very long, and the degradation of coenzyme Q10 will be accelerated in a humid and hot environment for a long time
In addition, in conventional tabletting, sticking and punching are very easy to occur, and it is relatively serious. After selecting excipients with better fluidity and adding lubricants, it still cannot be solved.
It is precisely because of a series of difficulties in the preparation process that there is currently no dosage form of coenzyme Q10 orally disintegrating tablets on the market

Method used

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  • Orally disintegrating tablet of coenzyme Q10 and preparation method thereof
  • Orally disintegrating tablet of coenzyme Q10 and preparation method thereof
  • Orally disintegrating tablet of coenzyme Q10 and preparation method thereof

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preparation example Construction

[0056] In the preparation method of the above-mentioned coenzyme Q10 orally disintegrating tablet, the tablet is pressed at a temperature of 20°C to 25°C and a relative humidity of 50% to 60%, and the speed of the tablet press is controlled at 20 rpm to 60 rpm It can effectively solve the problem of sticking and punching, so that the coenzyme Q10 orally disintegrating tablet can be industrialized and mass-produced smoothly.

[0057] In the present invention, the coenzyme Q10 can also be prepared into a solid dispersion, clathrate or microcapsule, and then prepared into an orally disintegrating tablet. In order to better illustrate the preparation method of the coenzyme Q10 orally disintegrating tablet, Example 11 is given as follows.

Embodiment 11

[0059] 1. Prescription:

[0060] Raw material - Coenzyme Q10 20g;

[0061] Capsule material— E100 15g;

[0062] Filler - mannitol 49g;

[0063] Disintegrant—low-substituted hydroxypropylmethylcellulose (L-HPC) 4g, croscarmellose sodium (CCNa) 3g;

[0064] Flavoring agent - stevioside 0.5g, orange essence 0.5g;

[0065] Lubricant—magnesium stearate 0.5g;

[0066] The total weight is 100g, and a total of 1000 tablets are made, 100mg / tablet, containing 20mg of coenzyme Q10.

[0067] 2. Preparation method

[0068] Step 1: Take E100 is made into a certain concentration solution with absolute ethanol, and it is used as a capsule material solution for later use;

[0069] Step 2: Take coenzyme Q10 and suspend it with vertical airflow to prepare microcapsules by air suspension method. The obtained coenzyme Q10 microcapsules are dried, passed through a 80-mesh sieve, and set aside;

[0070] Step 3: Mix mannitol, L-HPC, CCNa, stevioside and orange essence evenly, and then mix...

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Abstract

The invention discloses an orally disintegrating tablet of coenzyme Q10 comprising coenzyme Q10 as the main ingredient and auxiliary materials, wherein the weight proportions of the constituents include coenzyme Q10 5-50, crumbling agent 2-30, filling agent 40-200, flavoring agent 0-2, bonding agent 10-60, lubricating agent 0-5. The advantages of the tablet include shorter disintegration period, quick action, good taste, and fitting for mass production.

Description

technical field [0001] The invention relates to a coenzyme Q10 pharmaceutical preparation used for auxiliary treatment of cardiovascular diseases, hepatitis, cancer and other comprehensive diseases, in particular to a coenzyme Q10 orally disintegrating tablet preparation with rapid release and a preparation method thereof. Background technique [0002] Coenzyme Q10 is a hydrogen transporter of biological oxidation and an important coenzyme for energy production, metabolism and storage. It has been nearly 50 years since coenzyme Q10 was discovered in 1957. Due to its wide range of functions, it has been used in many diseases to varying degrees. Coenzyme Q10 is a prescription drug in my country, and SFDA currently approves this product for the adjuvant treatment of the following diseases: [0003] 1. Cardiovascular diseases, such as: viral myocarditis, chronic heart failure. [0004] 2. Hepatitis, such as: viral hepatitis, subacute hepatic necrosis, and chronic active hepati...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/122A61K9/20A61K47/00A61P35/00A61P9/00A61P1/16
Inventor 黄华喻咏梅胡雪莲
Owner 重庆市力扬医药开发有限公司