Process of producing nitrobenzether aminobenzether amidobenzether from chlorobenzene

A technology of amidophenylene ether and nitrophenylene ether, which is applied in the preparation of amino hydroxyl compounds, nitro compounds, carboxylic acid amides, etc., can solve the problems of large amount of three wastes, difficulty in treatment, high separation cost, etc., and achieve production cost Low, high production stability and safety effect

A technology of amidophenylene ether and nitrophenylene ether, which is applied in the preparation of amino hydroxyl compounds, nitro compounds, carboxylic acid amides, etc., can solve the problems of large amount of three wastes, difficulty in treatment, high separation cost, etc., and achieve production cost Low, high production stability and safety effect

CN100494159CInactive Publication Date: 2009-06-03CHANGZHOU JIASEN CHEM +1
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  • Process of producing nitrobenzether aminobenzether amidobenzether from chlorobenzene
  • Process of producing nitrobenzether aminobenzether amidobenzether from chlorobenzene
  • Process of producing nitrobenzether aminobenzether amidobenzether from chlorobenzene

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Embodiment 1

[0052] A clean production of o-nitroanisole, p-nitroanisole, anthranil, p-aminoanisole, 2,4-dinitroanisole, 2,4- The technique of diaminoanisole and 2-amino-4-acetamidoanisole, described processing step is as follows:

[0053] (1). Nitration reaction, using chlorobenzene as raw material, chlorobenzene is subjected to adiabatic nitration by mixed acid composed of nitric acid and sulfuric acid in a static mixed nitration reactor to obtain a mixture of nitrochlorobenzene, and the dehydration value of the mixed acid is between 2.0-3.2 Between, the ratio of chlorobenzene to nitric acid is 1:1.05. Continuous adiabatic nitration reaction occurs in continuous static mixer adiabatic nitration reactor. mixed with water

[0054] (2). Evaporation and concentration, after continuous adiabatic nitration reaction, the material is decompressed to 98.0kPa, water and residual nitric acid are distilled off, and then liquid-liquid separation;

[0055] (3). Liquid-liquid separation. The evaporat...

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Abstract

A process for preparing nitrophenylether, aminophenylether and amidophenylether between chlorobenzene and acid mixture removing water, liquid-liquid separation to obtain organic phase consisting of o-, p- and meta-nitro chlorobenzene compounds, etherifying said mixture, recovering etherifying agent, vacuum distilling, separating and refining meta-nitro chlorobenzene, removing chloride salt generated in etherification, crystallizing separation, recrystallizing p- and o-nitro phenylether compounds, catalytic hydrogenating reaction, nitrifying reaction to obtain 2,4-drinitro phenylether, catalytic hydroreducing reaction to obtain 2,4-diamino phenylether, and aceylating reaction to obtain 2-amino-4-acetylamino phenylether.

Description

technical field [0001] The invention relates to a process for producing nitrophenyl ether, aminophenyl ether and amidophenyl ether with chlorobenzene, belonging to the technical field of fine chemicals. Background technique [0002] Nitrophenyl ether, aminophenyl ether and amidophenyl ether are important intermediates in industries such as dyes, medicines, and spices. [0003] Nitrophenyl ether, aminoanisole and amidoanisole (mainly o-nitroanisole, p-nitroanisole, o-aminoanisole, p-aminoanisole, 2,4-dinitrobenzene The traditional production method of methyl ether, 2,4-diaminoanisole, 2-amino-4-acetamidoanisole, etc.) mainly uses chlorobenzene as raw material, and produces nitrochlorobenzene mixture through mixed acid nitration reaction, nitro The chlorobenzene mixture is separated by rectification-crystallization to obtain the finished products of o-nitrochlorobenzene, m-nitrochlorobenzene and p-nitrochlorobenzene, and the etherification reaction of p-nitrochlorobenzene and...

Claims

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Application Information

Patent Timeline
03 Jun 2009
Publication
CN100494159C
IPC
C07C201/08; C07C205/36; C07C213/02; C07C217/82; C07C233/07; C07C231/02
Inventors
许文林; 段玉辉