Lansoprazole intestine solution capsule and its preparation method
A technology for lansoprazole enteric and lansoprazole, which is applied in the field of lansoprazole enteric solution liquid capsule and its manufacturing field, can solve the problem that the temperature and humidity of lansoprazole raw materials are unstable, and hollow capsules cannot be directly filled. Serious environmental pollution and other problems, to achieve the effects of good product quality stability, avoidance of oxygen and moisture contact, and simple production process
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[0028] The lansoprazole raw material is pulverized, passed through a 200-mesh sieve for subsequent use, pregelatinized starch, polyoxyethylene 35 castor oil, magnesium oxide, poloxamer, sodium citrate, and gum arabic are distributed and pulverized, and passed through a 150-mesh sieve for subsequent use.
[0029] Take by weighing lansoprazole 150g, pregelatinized starch 300g, pulverize after mixing; Take by weighing camellia oil 1000g, polyoxyethylene 35 castor oil 150g, magnesium oxide 50g, poloxamer (188) 100g, sodium citrate 150g, Gum Arabic 100g, after mixing, add the mixture of lansoprazole and pregelatinized starch, grind in colloid mill after mixing, obtain lansoprazole medicine;
[0030] Add 150g of polyacrylic acid resin to dissolve in 1000ml of ethanol to form a solution, which is used as the capsule sealing material.
[0031] According to the content determination method in the national quality standard, measure the content of the active ingredients of the above drug...
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