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Traditional Chinese medicinal composition for treating fatty liver and its preparation method

A composition and fatty liver technology, which is applied to the traditional Chinese medicine composition for the treatment of fatty liver. In the field of preparation of the traditional Chinese medicine composition, it can solve the problems that the advantages of fatty liver cannot be brought into play, the reliability of the results has yet to be verified, and the treatment of decoction is inconvenient.

Inactive Publication Date: 2009-10-21
广州康臣药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the focus of the research is on the therapeutic level of decoction, and the literature reports that the cure rate is very high, but there is no strict double-blind comparison. There is no traditional Chinese medicine product officially approved by the state for the treatment of fatty liver, so the development of an effective, safe, controllable and stable new Chinese medicine product for the treatment of fatty liver has a huge market prospect
In addition, the course of treatment for fatty liver generally takes more than 3 months, and the treatment of decoction also brings a lot of inconvenience. Therefore, the market share of decoction treatment is not high, and the advantages of traditional Chinese medicine in the treatment of fatty liver cannot be brought into play.

Method used

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  • Traditional Chinese medicinal composition for treating fatty liver and its preparation method
  • Traditional Chinese medicinal composition for treating fatty liver and its preparation method
  • Traditional Chinese medicinal composition for treating fatty liver and its preparation method

Examples

Experimental program
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Effect test

Embodiment 1

[0136] The preparation of embodiment 1 soft capsule of the present invention

[0137] 750g of Polygonum cuspidatum and 667g of turmeric are crushed into coarse powder, extracted twice with 6 times the amount of ethanol under reflux, each time for 1 hour, the extracts are combined, filtered, and the filtrate is concentrated under reduced pressure at 60°C to a relative density of 1.36 (50°C). The thick paste is dried under reduced pressure at a temperature of 65°C and a vacuum of 0.087Mpa to form a dry extract, and then crushed into fine powder. Take 37.5g of silymarin and mix it evenly with fine powder. Add 8.3g of beeswax to 225g of evening primrose oil, heat until the beeswax melts, filter it with four layers of gauze while it is hot, add the mixed fine powder, and mix it with a colloid mill for 30 minutes. Dry it for 24 hours under the conditions of temperature 20°C and relative humidity 52%, take it out, wash it with ethanol, and dry it under the above conditions for 48 ho...

Embodiment 2

[0138] The preparation of embodiment 2 soft capsules of the present invention

[0139] 700g of Polygonum cuspidatum and 600g of turmeric are crushed into coarse powder, refluxed and extracted with 4 times the amount of ethanol for 3 times, each time for 0.5 hours, the extracts are combined, filtered, and the filtrate is concentrated under reduced pressure at 40°C to a relative density of 1.05 (50°C). The thick paste is dried under reduced pressure at a temperature of 40°C and a vacuum of 0.07Mpa to form a dry extract, and then crushed into fine powder. Take 30g of silymarin and mix it evenly with fine powder. Add 4g of beeswax to 100g of evening primrose oil, heat until the beeswax melts, filter it with four layers of gauze while it is hot, add the mixed fine powder, and mix it with a colloid mill for 60 minutes. Dry it for 24 hours under the conditions of 20°C and 52% relative humidity, take it out, wash it with ethanol, and dry it for 48 hours under the above conditions to ...

Embodiment 3

[0140] The preparation of embodiment 3 granules of the present invention

[0141] 1000g of Polygonum cuspidatum and 900g of turmeric are crushed into coarse powder, refluxed with 8 times the amount of ethanol and extracted once for 2 hours each time, the extracts are combined, filtered, and the filtrate is concentrated under reduced pressure at 80°C to a relative density of 1.50 (50°C). The thick paste is dried under reduced pressure at a temperature of 85°C and a vacuum of 0.12Mpa to form a dry extract, and then crushed into fine powder. Take 60g of silymarin, 150g of evening primrose oil and mix them evenly with fine powder, add an appropriate amount of sucrose, mix evenly, use 70% ethanol as a binder, granulate and dry to obtain granules.

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Abstract

The invention relates to a pharmaceutical composition for treating fatty liver and a preparation method thereof. The active ingredients contained in the traditional Chinese medicine composition are made from Polygonum cuspidatum, turmeric, silymarin and evening primrose oil. The pharmaceutical compositions of the present invention are tablets, soft capsules, capsules, dropping pills and granules. The traditional Chinese medicine composition of the invention has protective effect on acute liver injury, prevention and treatment effect on fatty liver, strong anti-peroxidative damage ability, blood lipid-lowering effect and blood rheology improvement effect on blood stasis syndrome, and can be used for treatment fatty liver.

Description

field of invention [0001] The invention relates to a traditional Chinese medicine composition, in particular to a traditional Chinese medicine composition for treating fatty liver, and also relates to a preparation method of the traditional Chinese medicine composition. Background technique [0002] Fatty liver has a high incidence rate in China and is a disease of modern civilization. It has a clear upward trend in recent years. Obesity, alcoholism, and diabetes are the three most common causes of fatty liver. Since some fatty liver patients can develop fatty liver hepatitis and liver fibrosis, and even lead to cirrhosis and its various complications, the prevention and treatment of fatty liver is of great significance to prevent the progression of chronic liver disease and improve the prognosis. Currently on the market for the treatment of fatty liver chemicals mainly include domestically produced Dongbao Gantai Tablets and imported Gandejian. adjuvant therapy. Domestic...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/9066A61K36/704A61K36/28A61K36/185A61K9/48A61K9/20A61K9/16A61P1/16
Inventor 黎倩
Owner 广州康臣药业有限公司
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