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Temperature sensing medicine carrying micelle with magnetothermal effect, preparation method and method of use thereof

A technology of drug-loaded micelles and magnetocaloric effect, which is applied in the directions of non-active ingredient medical preparations, medical preparations containing active ingredients, and pharmaceutical formulas, which can solve the problems of lack of cancer drugs and poor biocompatibility.

Inactive Publication Date: 2009-11-11
TONGJI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the existing manganese-zinc-ferrite materials for hyperthermia are generally used alone without the cooperation of relevant cancer treatment drugs; at the same time, because there is no polymer material package, the biocompatibility is poor

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Using benzoyl peroxide (BPO) as the initiator and 2-mercaptoethanol as the chain transfer agent, poly(N-isopropylacrylamide) (PNIPAAm) prepolymer containing terminal hydroxyl groups was synthesized. Then, the prepolymer containing terminal hydroxyl group is used as a macromolecular initiator, and Sn(Oct)2 is used as a catalyst to initiate ring-opening polymerization of lactide to obtain PNIPAAm-PLA block copolymer.

[0022] According to chemical composition: x=0.1 Weigh raw material: MnSO 4 ·H 2 O, ZnSO 4 ·7H 2 O, FeSO 4 ·7H 2 O, with NaOH as precipitant, according to n(M):n(OH - )=1:214 (M represents all metal ions) Weigh the required amount of NaOH and prepare a solution with a concentration of 10mg / ml. First mix the three sulfates and grind them into powder in a high-speed grinding cup, then add NaOH solution, while constantly stirring repeatedly to make a paste, after standing for 12 hours, dry at 80°C, after it is completely dry, re-grind and put it in a muff...

Embodiment 2

[0026] Polyisopropylacrylamide (PNIPAAm) was synthesized with benzoyl peroxide (BPO) as the initiator and 2-mercaptoethanol as the chain transfer agent.

[0027] According to the chemical composition: x=0.3 Weigh the raw material: MnSO 4 ·H 2 O, ZnSO 4 ·7H 2 O, FeSO 4 ·7H 2 O, with NaOH as precipitant, according to n(M):n(OH - )=1:214 (M represents all metal ions) Weigh the required amount of NaOH and prepare a solution with a concentration of 20mg / ml. First mix the three kinds of sulfates and grind them into powder in a high-speed grinding cup, then add NaOH solution, while constantly stirring repeatedly to make a paste, after standing for 12 hours, dry at 80°C, after it is completely dry, re-grind and put it in a muffle furnace for roasting at 400°C for 1 hour, after natural cooling, soak with hot distilled water and filter, To remove soluble sulfate, use BaCl2 to detect the absence of sulfate ions in the filtrate, then rinse with absolute ethanol, and dry at 60°C to o...

Embodiment 3

[0031] Lactide and PEG are used to initiate ring-opening polymerization and copolymerization to obtain block copolymer PLA-PEG.

[0032] According to chemical composition: x=0.1 Weigh raw material: MnSO 4 ·H 2 O, ZnSO 4 ·7H 2 O, FeSO 4 ·7H 2 O, with NaOH as precipitant, according to n(M):n(OH - )=1:214 (M represents all metal ions) Weigh the required amount of NaOH and prepare a solution with a concentration of 10mg / ml. First mix the three sulfates and grind them into powder in a high-speed grinding cup, then add NaOH solution, while constantly stirring repeatedly to make a paste, after standing for 12 hours, dry at 80°C, after it is completely dry, re-grind and put it in a muffle furnace for roasting at 400°C for 1 hour, after natural cooling, soak with hot distilled water and filter, To remove soluble sulfate, use BaCl 2 After detecting that there is no sulfate ion in the filtrate, rinse it with absolute ethanol once, and dry it at 60° C. to obtain manganese-zinc ferrit...

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Abstract

The invention relates to the preparation and application method of a temperature sensitive micelle with magnetocaloric effect, belonging to the field of drug carrier in biological medicine, which adopts the technical proposal that: a quantity of temperature sensitive polymer is dissolved into an organic solvent; then the organic solvent together with drugs and Mn-Zn ferrite nanometer particles undergoes dialysis process in a great amount of deionized water to get a temperature sensitive micelle with magnetocaloric effect; and finally after certain biological treatment, the micelle is injected into human body; which is characterized in that an outside magnetic field locates the drug carrier near the tumor site; at the same time an alternating magnetic field raises the temperature of the micelle to reach the lowest critical temperature, so that the drug is released at the shrinking of the micelle. The method has an advantage that a new type of bio-control sustained release carrier is provided for the field of biological medicine.

Description

technical field [0001] The invention belongs to the technical field of drug carriers in biomedicine, and in particular relates to a temperature-sensitive drug-loaded micelle with magnetocaloric effect, a preparation method and a use method thereof. Background technique [0002] Cancer is one of the main diseases that endanger human life and health at present. In order to conquer this stubborn disease, people have studied and tried many kinds of treatment methods, including surgical resection, chemotherapy, radiotherapy, hyperthermia and starvation therapy. But for now, all kinds of therapies are unsatisfactory in curative effect because they cannot avoid certain therapeutic limitations and side effects. Heat therapy among them has obtained some results through years of development, from the initial heat treatment to the outside to the internal heat treatment. In recent years, research on magnetic media hyperthermia (magnetic media hyperthermia) using material magnetocaloric...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/34A61K47/32A61K47/02A61K35/00
Inventor 任杰贾梦虹谭庆刚任天斌
Owner TONGJI UNIV
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