Body lumen drug-carrying bracket and preparation method thereof

Abstract

The invention discloses a body lumen drug-carrying bracket and a preparation method thereof. The body lumen drug-carrying bracket comprises a bracket body. A plurality of holes are uniformly distributed on the outer circumferential surface of the bracket body. Drugs are carried in the plurality of holes. The inside surface of the bracket body is a smooth surface. After the body lumen drug-carrying bracket provided by the embodiment of the invention is implanted in a human body, the problems resulted from polymer drug-carrying can be avoided; furthermore, the body lumen drug-carrying bracket only releases drugs on vascular walls contacted with micro-holes on the outer circumferential surface, therefore, the targeted release drugs can be realized; and the controlled release ability and the effective utilization rate of drugs can be increased.

Description

technical field [0001] The present application relates to the field of medical devices, in particular to a drug-loaded stent in a human lumen and a preparation method thereof. Background technique [0002] In recent years, drug-loaded stents have been widely used clinically. Drug-loaded stents are also called drug-releasing stents, which carry drugs through polymers coated on the surface of metal stents or through holes on the surface of metal stents. Compared with bare metal stents, after being implanted in the human body, drug-loaded stents can continuously release drugs to the diseased tissues in contact with them, thereby effectively inhibiting the proliferation of smooth muscle on the inner wall of blood vessels and reducing the occurrence of restenosis in stents. [0003] However, through the research on the prior art, the applicant found that the existing human lumen drug-loaded stent has the following problems: 1. After long-term implantation of the drug-loaded sten...

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Problems solved by technology

[0003] However, through the research on the prior art, the applicant found that the existing human lumen drug-loaded stent has the following problems: 1. After long-term implantation of the drug-loaded stent using the polymer to carry the drug, due to the polymer on the surface of the drug-loaded stent Long-term presence or degradation of the polymer leads to a persistent inflammatory response that may lead to delayed endothelialization and late restenotic catch-up

2. The drug-loaded stent that uses the holes on the surface of the metal stent to carry drugs, because the entire surface of the metal stent is provided with micropores, the inner and outer surfaces and even the sides of the drug-loaded stent are coated with drugs, so when implanted into the human body Finally, the concentration of the drug in the blood vessel will be large, and the release direction will not be effectively controlled, so that part of the drug cannot be absorbed by the blood vessel wall, and the effective utilization rate of the drug is low.

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