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Method for preparing monodisperse magnetic silica dioxide nano particles

A technology of silica and nanoparticles, applied in the direction of silica, etc., can solve the problems of magnetic silica nanoparticles size, dispersion and particle surface modification, etc., to achieve good dispersion and biological activity High, uniform particle size effect

Inactive Publication Date: 2009-12-09
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] However, the size, dispersion and surface modification of magnetic silica nanoparticles have not been well resolved.

Method used

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  • Method for preparing monodisperse magnetic silica dioxide nano particles
  • Method for preparing monodisperse magnetic silica dioxide nano particles
  • Method for preparing monodisperse magnetic silica dioxide nano particles

Examples

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Embodiment 1

[0034] Weigh 2.16g (0.008mol) FeCl 3 ·6H 2 O and 1.11g (0.004mol) FeSO 4 ·7H 2 O was dissolved in 40ml of deionized water, and under the protection of nitrogen at room temperature, 20ml of ammonia water with a concentration of 1.5mol / l was added point by point to the above solution to obtain a black precipitate. The precipitate was fully washed 5 times with deionized water by means of magnetic separation to obtain a black precipitate for future use. Under stirring conditions, 0.0009g Fe 3 o 4 The precipitate was pipetted into a solution of 0.8ml ethanol and 20ml water, and the solution contained 0.00009g sodium oleate. The pH value of the above reaction system was adjusted to 6 with 0.1 mol / l perchloric acid. Add 0.015g of sodium silicate to the above reaction system, then raise the temperature to 80°C, and maintain the temperature for ultrasonic dispersion for 30min. After the sonication is finished, turn to room temperature and add 30 μl (3-mercaptopropyl)trimethoxysi...

Embodiment 2

[0036] Weigh 2.16g (0.008mol) FeCl 3 ·6H 2 O and 1.11g (0.004mol) FeSO 4 ·7H 2 O was dissolved in 40ml of deionized water, and under the protection of nitrogen at room temperature, 20ml of ammonia water with a concentration of 1.5mol / l was added point by point to the above solution to obtain a black precipitate. The precipitate was fully washed 5 times with deionized water by means of magnetic separation to obtain a black precipitate for future use. Under stirring conditions, 0.0009g Fe 3 o 4 The precipitate was pipetted into a solution of 0.8ml ethanol and 20ml water, and the solution contained 0.00009g sodium oleate. The pH value of the above reaction system was adjusted to 6 with 0.1 mol / l perchloric acid. Add 30 μl of (3-mercaptopropyl)trimethoxysilane (MPS) and 0.015 g of sodium silicate to the above reaction system, then raise the temperature to 80° C., and maintain the temperature for ultrasonic dispersion for 30 minutes. After the sonication is finished, turn to...

Embodiment 3

[0038] Weigh 2.16g (0.008mol) FeCl 3 ·6H 2 O and 1.11g (0.004mol) FeSO 4 ·7H 2 O was dissolved in 40ml of deionized water, and under the protection of nitrogen at room temperature, 20ml of ammonia water with a concentration of 1.5mol / l was added point by point to the above solution to obtain a black precipitate. The precipitate was fully washed 5 times with deionized water by means of magnetic separation to obtain a black precipitate for future use. Under stirring conditions, 0.0009g Fe 3 o 4 The precipitate was pipetted into a solution of 0.8ml ethanol and 20ml water, and the solution contained 0.00009g sodium oleate. The pH value of the above reaction system was adjusted to 5.6 with 0.1 mol / l perchloric acid. Add 0.015g of sodium silicate to the above reaction system, then raise the temperature to 70°C, and maintain the temperature for ultrasonic dispersion for 30min. After the sonication is finished, turn to room temperature and add 40 μl of (3-mercaptopropyl)trimeth...

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Abstract

The invention relates to a preparation method of monodisperse magnetic silicon dioxide nanoparticles, comprising the following steps: (1) adding excess ammonia water to an aqueous solution containing Fe3+ and Fe2+ salts under nitrogen at room temperature to obtain black precipitate Fe3O4; (2) precipitating Transfer to the alcoholic aqueous solution of sodium oleate, adjust the pH value to acidity; (3) add sodium silicate, heat up, and ultrasonically form dispersed magnetic silica nanoparticles; (4) add coupling agent to react to obtain surface-modified Monodisperse Magnetic Silica Nanoparticles. The raw material price of this method is low, the process is simple, the number of required equipment is small, and the energy consumption is low. The prepared magnetic silica nanoparticles have good performance and can be more comprehensively satisfied with drug carriers, enzyme immobilization, cell Sorting, immunoassay and nucleic acid separation and hybridization and other fields of application requirements.

Description

technical field [0001] The invention belongs to a preparation method of silica nanoparticles, in particular to a preparation method of monodisperse magnetic silica nanoparticles. Background technique [0002] In recent years, many organic and inorganic materials have been widely used to coat superparamagnetic nano-Fe 3 o 4 Particles, including natural polymers (such as albumin, chitosan, starch and gelatin, etc.), synthetic polymers (such as polystyrene, polymethyl methacrylate, polylactic acid and polycaprolactone, etc.) and inorganic Materials (such as silicon dioxide and nano-carbon, etc.). Such core-shell composite particles are favored due to their unique advantages in electrical, optical, magnetic, catalytic, and mechanical properties. [0003] In the field of drug delivery, organic composite particles are limited by their poor thermal and chemical stability and their rapid clearance by the immune system. On the contrary, inorganic composite particles have the foll...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C01B33/113
Inventor 陈志龙黄鹏周兴平
Owner DONGHUA UNIV
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