Quantitative Monte Carlo simulation method for light transfer characteristic in biological tissue

Abstract

A quantitative Monte Carlo simulation method for transmission characteristics of light in a biological tissue pertains to the application of spectrum technology; the method firstly describes a spatial structure of the target biological tissue as a three-dimensional digital matrix, the surface characteristics of an incident light source are a set of photons with the set number, the position of the incident light source and the direction of the incident light are given to the initial position and the direction of each photon; the transmission process of each photon is tracked, and then a light absorption matrix and the information of all escaped photons are output. The method quantitatively simulates the light transmission characteristics in any biological tissue with three-dimensional structure by establishing a Monte Carlo model of transmitting the light in the tissue. The method has high precision and good stability, which can obtain the rich characteristics of the light transmission in the real biological tissue. The application of the method can optimize the design of a biological tissue optical detection / imaging system, provide precise information for the dose quantification for light treatment and provide an accurate and reliable tool for the positioning of a detection area and the quantitative analysis of signals in the biological tissue by using the spectrum technology.

Description

technical field [0001] The invention belongs to the fields of spectral technology application, mathematical simulation and biomedical engineering, and relates to a quantitative Monte Carlo simulation method of light transmission characteristics in tissues. Background technique [0002] The application of spectroscopic technology to the detection and imaging of biological tissues has the advantages of non-invasive measurement, high time resolution, and low cost compared to existing mature technologies such as PET, fMRI, EMG / ECG / EEG, etc. It is of great significance to disease diagnosis and monitoring, optical clinical treatment, brain function mechanism and physiological and pathological research. In recent years, spectroscopic technology has been widely praised in the research and clinical application of biological tissue detection imaging, but its accuracy and reliability have not been widely accepted. The reason is that light, especially the most commonly used near-infrare...

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Problems solved by technology

Among them, the 'MCML' method (S.L.Jacques and L.Wang. "Monte Carlo modeling of light transport intissues," in 1995 Proc OPTICAL-THERMAL RESPONSE OFLASER-IRRADIATED TISSUE Conf., PP.73-99. and L.Wang, S.L. Jacques, and L. Zheng, "MCML--Monte Carlo modeling of light transport inmulti-layered tissues, "Comput.Methods.Programs.Biomed., vol.47, pp.131-146, 1995.) is the most widely used in the world Broad and the most accurate method, but this method is only suitable for simplified biological tissues with columnar multilayers, and cannot be used for biological tissues with complex three-dimensional structures

In addition, in recent years, a new method developed abroad that can be used in three-dimensional biological tissues - 'tMCimg' (D.A.Boas, J.P.Culver, J.J.Stott, and A.K.Dunn, "Threedimensional Monte Carlo code for photon migration through complex heterogeneous media including the adult human head, "Opt.Express., vol.10, no.3, pp.159-170, 2002.), has the disadvantages of tissue model limitations and low accuracy

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