Usage of eleutheroside with anti-inflammatory action or aglycone thereof

A technology of aglycone and inflammation, which is applied in the field of medical application of arachnid and its aglycone, which can solve the problems of lagging intervention methods and unsatisfactory curative effect of liver failure
CN100591334CInactive Publication Date: 2010-02-24CENT SOUTH UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
CENT SOUTH UNIV
Publication Date
2010-02-24
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to a medical usage of eleutheroside and the aglycone thereof, in particular to the application of the glycoside with the following formula I or the aglycone with the formula II in the preparation of the drugs for the diseases caused by inflammatory mediators, wherein, the inflammatory mediators are HMGB1, TNF-Alpha or IL-1 particularly. The glycoside of R1 R2 R3 R4 formula Iis: H COOH H-Beta-D-glc6-Beta-D-glc4-Alpha-L-rha, and the aglycone of formula II is: H COOH H H.
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Description

technical field

[0001] The present invention relates to the medical use of araquinoside and its aglycone, more specifically, the application of the glycoside represented by the following formula I or the aglycone represented by formula II in the preparation of medicines for diseases caused by inflammatory mediators.

[0002]

[0003] R1 R2 R3 R4

[0004] Glycoside of formula I: HCOOHH-β-D-glc6-β-D-glc4-α-L-rha

[0005] Aglycone of formula II: H COOH H H Background technique

[0006] High mobility group box chromosomal protein 1 (HMGB1) is one of the members of the high mobility group box superfamily and is an abundant non-histone nuclear protein. It consists of 214 amino acids, has the function of regulating transcriptional activity, and can promote cell proliferation. HMGB1 becomes an inflammatory mediator, can interact with various inflammatory mediators, participates in the pathogenesis of sepsis, and is an important inflammatory mediator in the late sta...

Claims

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