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Application of Qishen Yiqi dripping pills for preparing medicine to inhibit degranulation of labrocyte

A technique for Qishen Yiqi dripping pills and mast cells, which is applied in the field of medicine

Active Publication Date: 2010-03-03
TIANJIN TASLY PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Chinese patent CN1375316A discloses the composition, preparation method and use of the preparation in angina pectoris of coronary heart disease, but the effect of the drug on anti-mast cell degranulation and improving microcirculation has not been reported yet

Method used

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  • Application of Qishen Yiqi dripping pills for preparing medicine to inhibit degranulation of labrocyte
  • Application of Qishen Yiqi dripping pills for preparing medicine to inhibit degranulation of labrocyte

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Take 86.5g of Astragalus, 21.3g of Salvia, 3.5g of Panax notoginseng, 20.6g of Dalbergia odorifera, and 30g of polyethylene glycol-6000 as an auxiliary material. Decoct crushed Salvia miltiorrhiza and Panax notoginseng twice in water, add 7 times the amount of water each time for 2 hours, combine the decoction, filter, and concentrate the filtrate to 900ml, add 95% ethanol to make the alcohol concentration reach 70%, let stand for 12-24 hours, filter, recover ethanol, and concentrate into extract with relative density of 1.32~1.38 (50~60℃); decoct the crushed astragalus with water twice, add 6 each time Double the amount of water, extract for 2 hours and 1 hour in turn, combine the filtrate, when concentrated to about 1500ml, add 95% ethanol to make the alcohol concentration 60%, let stand for 12-24 hours, filter, and recover the ethanol from the filtrate and concentrate to about 400ml At the time, add 95% ethanol to make the alcohol concentration 80%, let stand for 12-2...

Embodiment 2

[0040] Take 40.6g of Astragalus, 44.8g of Salvia, 11.2g of Panax notoginseng, 38.6g of Dalbergia odorifera, 30g of adjuvant polyethylene glycol-6000, and prepare the traditional Chinese medicine preparation of the present invention according to the preparation process of Example 1.

Embodiment 3

[0042] Take 77.3g of Astragalus, 22.8g of Salvia miltiorrhiza, 4.8g of Panax notoginseng, 30.5g of Dalbergia odorifera, and 28g of polyethylene glycol-6000 as the auxiliary material, and prepare the traditional Chinese medicine preparation of the present invention according to the preparation process of Example 1.

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Abstract

An application of the 'Qi-replenishing' Qishen dripping pill in preparing the medicines for preventing and treating the microcirculatory disturbance diseases caused by mast cell degranulating is disclosed.

Description

Technical field [0001] The invention belongs to the field of medicine, and specifically relates to the application of Qishen Yiqi dripping pills in preparing medicines for inhibiting degranulation of mast cells. Background technique [0002] Degranulation of mast cells is a complex biochemical process and is affected by various stimuli. Classical theory believes that after the allergen is bridged with the IgE molecules on the surface of mast cells, the IgE molecules are allosterically changed. The latter changes the energy metabolism and permeability of the mast cell membrane, and promotes the phospholipid methylation process and calcium ion channels of the cell membrane. open. The influx of calcium ions in the extracellular fluid may lead to the fusion of the granular surrounding membrane and the cell membrane through the activity of the microfilaments in the brain plasma (cell muscle action), and together with the mutual fusion between the granular surrounding membrane, formin...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/53A61K36/481A61K36/48A61K36/258A61K9/20A61P43/00
Inventor 韩晶岩李旭郑永峰叶正良
Owner TIANJIN TASLY PHARMA CO LTD