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Infusion preparation of ibuprofen and preparation method thereof

A preparation and co-solvent technology, applied in the field of medicine, can solve the problems of low bioavailability, easy cross-infection, low solubility, etc., and achieve high bioavailability, short production cycle, and rapid onset of effect

Inactive Publication Date: 2007-11-28
汪洪湖
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] Currently, ibuprofen and dexibuprofen have common preparations such as tablets, capsules, dispersible tablets, and oral suspensions in clinical practice. Like other non-steroidal anti-inflammatory drugs (NSAIDs), they have low solubility, slow absorption, biological The utilization is low and the onset is relatively slow, whi

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0025] Example 1: ibuprofen glucose infusion

[0026] Prescription: ibuprofen 200g

[0027] Arginine 169g

[0028] Glucose 5000g

[0029] Propylene Glycol 20ML

[0030] EDTA-2Na 0.2g

[0031] Sodium sulfite 5g

[0032] Water for injection Add to total volume 100000ML

[0033] Using water for injection and propylene glycol volume ratio of 5:1 as a mixed solvent, add ibuprofen and arginine in the recipe quantity, stir to dissolve completely (necessary heating), then add EDTA-2Na and sodium sulfite, and dilute to 5000ML with an appropriate amount of water (adjust PH to 4.5-7.5 if necessary), add 0.1% activated carbon. Incubate at 70°C for more than 20 minutes, filter and decarburize, and prepare a concentrated solution of ibuprofen 40mg / ML for later use; take the prescribed amount of glucose and add it to 10000ML water for injection at 70°C to dissolve, add 0.1% activated carbon, and keep for 20 minutes Above, filter and decarburize, prepare a concentrated solution of gluc...

Example Embodiment

[0034] Example 2: Ibuprofen Sodium Chloride Infusion

[0035] Prescription: ibuprofen 200g

[0036] Arginine 10g

[0037] Sodium Chloride 900g

[0038] Propylene Glycol 800ML

[0039] EDTA-2Na 0.2g

[0040] Sodium sulfite 5g

[0041] Water for injection Add to total volume 100000ML

[0042] Using water for injection and propylene glycol volume ratio of 5:1 as a mixed solvent, add ibuprofen and arginine in the recipe quantity, stir to dissolve completely (necessary heating), then add EDTA-2Na and sodium sulfite, and dilute to 5000ML with an appropriate amount of water (adjust PH to 4.5-7.5 if necessary), add 0.1% activated carbon. Incubate at 70°C for more than 20 minutes, filter and decarbonize, and prepare a 40mg / ML concentrated solution of ibuprofen for later use; add sodium chloride in the recipe amount to 10000ML water for injection at 70°C to dissolve, add 0.1% activated carbon, and keep warm For more than 20 minutes, filter and decarburize, prepare a concentrated ...

Example Embodiment

[0043] Example 3: Dexbuprofen Dextrose Infusion

[0044] Prescription: Dexibuprofen 200g

[0045] Lysine 141g

[0046] Glucose 5000g

[0047] Propylene Glycol 3ML

[0048]EDTA-2Na 0.2g

[0049] Sodium sulfite 5g

[0050] Water for injection Add to total volume 100000ML

[0051] With water for injection and propylene glycol volume ratio of 5:1 as a mixed solvent, add dexbuprofen and lysine of the recipe quantity, stir to dissolve it completely (necessary heating), then add EDTA-2Na and sodium sulfite, dilute with an appropriate amount of water to 5000ML (adjust PH to 4.5-7.5 if necessary), add 0.1% activated carbon. Incubate at 70°C for more than 20 minutes, filter and decarburize, and prepare a 40mg / ML concentrated solution of dexbuprofen for later use; take the prescribed amount of glucose and add it to 10,000ML water for injection at 70°C to dissolve, add 0.1% activated carbon, and keep warm for 20 More than 10 minutes, filter and decarburize, prepare into concentrate...

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Abstract

The present invention provides one kind of brufen transfusion preparation and its preparation process, and features that the brufen transfusion preparation is prepared with brufen as main component, glucose or sodium chloride, alkaline cosolvent, propylene glycol or alcohol, sodium bisulphate, EDTA-2Na and water for injection, and through a certain technological process. The brufen transfusion preparation is superior to common orally taken brufen preparation and injection, and has short production period, high bioavailability, fast acting and other advantages.

Description

Technical field: [0001] The invention belongs to the technical field of medicines, and in particular relates to an ibuprofen transfusion preparation for treating pain and fever caused by various reasons and a preparation method thereof. Background technique [0002] Ibuprofen, namely 2-(4-isobutylphenyl)propionic acid, is a non-steroidal anti-inflammatory drug (NSAIDs) and is the first ibuprofen drug used clinically and is still widely used in the world. It is recognized as one of the safest drugs among NSAIDs. Pharmacological action shows its anti-inflammatory, analgesic and antipyretic effects. Clinically used for various acute and chronic arthritis, soft tissue rheumatism, tenosynovitis, sports injuries and headaches, myalgia, dysmenorrhea, pain after tooth extraction, and cancer pain. The drug is recommended as the first step drug in the analgesic drug ladder, which is recorded in domestic and foreign pharmacopoeias and is one of the basic drugs in my country. Due to s...

Claims

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Application Information

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IPC IPC(8): A61K31/192A61K9/08A61K47/16A61K47/10A61P29/00A61P19/02A61P19/04
Inventor 汪洪湖
Owner 汪洪湖
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