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Method for preparing total saponins of platycodon grandiflorum

A technology for total saponins and platycodon grandiflorum is applied in the field of preparation of total saponins from platycodon grandiflorum, can solve problems such as unfavorable industrialized production, complicated operation, large consumption, etc., and achieves the effects of easy industrialized large-scale production, high physiological activity, and high extraction and separation efficiency.

Inactive Publication Date: 2007-12-12
TIANJIN TASLY ZHIJIAO PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The main active ingredient of platycodon is platycodon saponin. The traditional preparation method of platycodon platycodon is high in cost, consumes a large amount of reagents such as acetone and ether, and is complicated to operate, which is not conducive to industrial production. Therefore, it is necessary to find a new extraction and separation method to make it suitable. in industrial production

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Take the platycodon root medicinal material, pulverize, add water and boil to extract three times and control the pH, the first time is 6 times the amount of water and 0.7% of the amount of Na2CO3, the second time is 4 times the amount of water and 0.3% of the amount of Na2CO3, The third time is 4 times the water volume of the medicinal material; side countercurrent circulation extraction, and keep it for 1.5, 1, and 1 hour respectively after boiling; the medicinal liquid is combined and cooled to room temperature, filtered, and the macroporous weakly basic anion D392 that has been treated on the filtrate Exchange column (Nankai University Chemical Plant), rinse with 2% NaOH solution of 2 times the volume of the resin bed, discard the rinse solution; rinse with pure water 3 times, discard the rinse solution with water; use 70% ethanol with 7 times the volume of the resin bed Elution, collect the eluent, concentrate to a thick paste (relative density at 50°C is 1.28-1.33)...

Embodiment 2

[0017] Take the platycodon root, crush it, add water and ultrasonically extract it four times and control the pH, the first time is 5 times the amount of water and 0.9% of the amount of NaHCO3, the second time is 4 times the amount of water and 0.5% of the amount of NaHCO3 , the third and fourth times are 3 times the amount of water; the medicinal liquid is combined and cooled to room temperature, filtered, and the treated macroporous type weakly basic anion D380 exchange column (Nankai University Chemical Plant) on the medicinal liquid filtrate, Rinse with 2.5% NaOH solution 1.5 times the volume of the resin bed, discard the rinse solution; then rinse with pure water 4 times, discard the water rinse solution; elute with 65% ethanol 8 times the volume of the resin bed, collect the eluate, and concentrate To a thick paste (relative density is 1.28-1.33 at 50° C.), dry with dynamic belt drying equipment to obtain total saponins of Platycodon grandiflora (total saponin yield 7.5%)...

Embodiment 3

[0019] Get the platycodon root, crush it, add 50% ethanol to reflux and extract three times and control the pH, the first time is 5 times the amount of the medicinal material 50% ethanol and 1% Na2CO3, the second time is 4 times the amount of the medicinal material 50% ethanol amount and 0.5% Na2CO3 of the amount of medicinal material, the third time is 4 times the amount of 50% ethanol of the amount of medicinal material; side countercurrent circulation reflux extraction, after the reflux starts, keep respectively for 1.5, 1, and 1 hour; filter the medicinal liquid and combine the filtrate, the filtrate 70 After concentrating under reduced pressure at ℃ until there is no alcohol smell, the concentrated solution is diluted with water until the ratio of medicinal materials to liquid is 1:1.5, filtered, and the filtrate is treated with a macroporous strong basic anion D201 exchange column (Nankai University Chemical Factory), Rinse with 2% NaOH solution 2 times the volume of the ...

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PUM

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Abstract

The invention discloses a preparation method of total saponins fromPlatycodon grandiflorum which comprises in sequence adding Platycodon grandiflorum into solvent, regulating to alkality, extracting, loading on macroporous basic anion-exchange column, eluting with alkali solution and pure water, discarding the flushing liquor, eluting with aqueous ethanol to give eluant, and concentrating. The inventive preparation method of Platycodon grandiflorum total saponins has high extraction separation efficiency, high total saponins yield, high biological activity preservation, and easy industrialization production.

Description

technical field [0001] The invention belongs to a preparation method of a traditional Chinese medicine extract, in particular to a preparation method of platycodon grandiflorum total saponins. Background technique [0002] Platycodon grandiflorum is the dried root of Campanulaceae plant Platycodon grandiflorum (Jacq.) A.DC. It is one of the traditional commonly used antitussive and expectorant drugs. Modern pharmacological studies have shown that platycodon grandiflorum has a wide range of effects such as expectorant, antitussive, anti-inflammatory, inhibition of gastric acid secretion, anti-gastric ulcer, sedation, antipyretic, analgesic, hypoglycemic, hypolipidemic and cholesterol-lowering. Prescription and clinical. In addition, Platycodon grandiflorum is a plant with the same origin as medicine and food. Therefore, the market demand is very large. The main active ingredient of platycodon is platycodon saponin. The traditional preparation method of platycodon platycodon...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/34A61K9/20A61K47/34A61P11/14A61P11/10A61P1/04A61P3/06A61P3/10A61P29/00A61K125/00A61K47/10
Inventor 杨悦武叶正良郑永锋李旭
Owner TIANJIN TASLY ZHIJIAO PHARMA
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