Casein derived peptides and therapeutic uses thereof

Abstract

Biologically active peptides that are derived from or are similar to sequences of the alphaS1-, alphaS2-, beta- or kapa-casein fractions of milk casein. These peptides are capable of immune modulation and other therapeutic activities, including but not limited to stimulating and enhancing immune response, protecting against viral infection, normalizing serum cholesterol levels, and stimulating hematopoiesis. The casein-derived peptides are non-toxic and can be used to treat and prevent immune pathologies, diabetes, hypercholesterolemia, hematological disorders and viral-related diseases.

Description

Technical field [0001] The present invention relates to biologically active peptides derived from or similar to the sequence of αS1-, αS2-, β- or κ-casein fragments of casein. These peptides can immunomodulate and other therapeutic activities, including but not limited to stimulating and enhancing immune responses, preventing viral infections, normalizing serum cholesterol levels, and stimulating hematopoiesis. Casein-derived peptides are non-toxic and can be used to treat and prevent immunopathology, diabetes, hypercholesterolemia, hematopoietic diseases and virus-related diseases. Background technique [0002] Bioactive molecules from nutrients: [0003] In addition to the nutritional value of many foods, certain fragments and products of the digestive pathway have the ability to affect physiological processes. Some of these "extra-nutritive" ingredients are present in their entire nutrients in their active form, such as immunoglobulins in breast milk and colostrum, phytoestrog...

AI Technical Summary

Problems solved by technology

[0029] Previous studies have documented that potentially bioactive peptides are encoded in the N-terminus of αS1-casein, αS2-casein, β-casein, and κ-casein in the amino acid sequences, but did not mention the application, specific Sequence or defined synthetic peptides, alone or in combination, to enhance hematopoiesis, protect against viral infection, or modulate the development of autoimmune diseases

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