Diffluent antibacterial drugs composition pharmaceutical formulation, method of preparing the same and use thereof

A technology of pharmaceutical preparations and antibacterial drugs, which is applied in the field of medicine and can solve the problems of large solvents, increased processes, and increased related substances.

Inactive Publication Date: 2008-02-27
刘力
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The compound preparation (8:1) or (4:1) composed of piperacillin sodium and tazobactam sodium, in order to increase the solubility, usually put tazobactam sodium or piperacillin sodium and tazobactam sodium together After freeze-drying, crush and repackage, especially when piperacillin sodium and tazobactam sodium are freeze-dried together, the amount of solvent water used is particularly large, which increases energy consumption a lot, increases the process, and the production and processing time is longer than the direct aseptic The powder packaging has increased hundreds of times, but the effect is still unsatisfactory
Because the β-lactam ring is easy to hydrolyze, the β-lactam compound is easy to degrade in the solution state, and the related substances will increase after being placed for a long time, which brings great hidden dangers to the safety of medication

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] Embodiment 1: Under GMP condition, this antimicrobial combination pharmaceutical preparation is made of 1000 grams of aseptic piperacillin sodium and tazobactam sodium (8: 1) with a particle size of 100 mesh and 200 mesh of sterile L-sperm Amino acid 1g is fully mixed, operated according to the powder injection preparation process, and divided into about 222 bottles;

Embodiment 2

[0047] Embodiment 2: Under GMP condition, this antimicrobial combination pharmaceutical preparation is fully mixed by 100 order sterile piperacillin sodium and tazobactam sodium (4: 1) 200 grams and 100 order sterile sodium carbonate 1g, press powder injection The preparation process is operated, and it is divided into about 20-80 bottles;

Embodiment 3

[0048] Embodiment 3: Under GMP condition, this antibacterial combination pharmaceutical preparation is fully mixed by sterile piperacillin sodium and tazobactam sodium (4: 1) 100 grams and sterile L-arginine 400 g, and is prepared by powder injection Process procedure operation, approximately divided into 20-80 bottles;

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PUM

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Abstract

The invention relates to an easily soluble antibacterial drug agent, making method and application, which consists of component A and component B with weight ratio at 100:0. 1 to 1:10, wherein the component A is piperacilliin or other physiological medicinal salt or hydrate, or tazobactam or other physiological medicinal salt or hydrate or the composition of piperacilliin or other physiological medicinal salt or hydrate and tazobactam or other physiological medicinal salt or hydrate, and the component B is pharmacy Lewis acid or Lewis base comprising soluble alkaline metals or salt of alkaline-earth metal, soluble organic base, organic acid or one or some kinds of salt of the both. The invention has merits of good water-solubility to solve fast and extend solubility, which is fit for anti-infectious treatment and precaution of bacillary diseases to human and animals.

Description

technical field [0001] The invention relates to the technical field of medicine, and specifically provides an easily soluble antibacterial combined drug preparation, preparation method and application. Background technique [0002] Piperacillin is a semi-synthetic ureidopenicillin with broad antibacterial spectrum and strong antibacterial activity. Piperacillin is more sensitive to Staphylococcus aureus, Staphylococcus epidermidis, and Bacillus anthracis. Gram-negative bacteria, Neisseria, Escherichia coli, influenza bacillus, Flavobacterium, Pseudomonas aeruginosa, Pseudomonas alcaligenes, Pseudomonas putrefaciens, Burkholderia cepacia, Salmonella typhi bacteria, Pseudomonas aeruginosa, Klebsiella and most Enterobacteriaceae including Citrobacter, cephalothin-resistant Enterobacter, Serratia, Vibrio, cloacae, Acinetobacter, Proteus Bacillus has a high antibacterial activity, and its effect is stronger than that of ampicillin. A variety of anaerobic bacteria (including Ba...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/431A61K31/43A61K9/08A61K47/12A61K47/02A61P31/04
Inventor 刘力
Owner 刘力
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