Diffluent antibacterial drugs composition pharmaceutical formulation, method of preparing the same and use thereof

Abstract

The invention relates to an easily soluble antibacterial drug agent, making method and application, which consists of component A and component B with weight ratio at 100:0. 1 to 1:10, wherein the component A is piperacilliin or other physiological medicinal salt or hydrate, or tazobactam or other physiological medicinal salt or hydrate or the composition of piperacilliin or other physiological medicinal salt or hydrate and tazobactam or other physiological medicinal salt or hydrate, and the component B is pharmacy Lewis acid or Lewis base comprising soluble alkaline metals or salt of alkaline-earth metal, soluble organic base, organic acid or one or some kinds of salt of the both. The invention has merits of good water-solubility to solve fast and extend solubility, which is fit for anti-infectious treatment and precaution of bacillary diseases to human and animals.

Description

technical field [0001] The invention relates to the technical field of medicine, and specifically provides an easily soluble antibacterial combined drug preparation, preparation method and application. Background technique [0002] Piperacillin is a semi-synthetic ureidopenicillin with broad antibacterial spectrum and strong antibacterial activity. Piperacillin is more sensitive to Staphylococcus aureus, Staphylococcus epidermidis, and Bacillus anthracis. Gram-negative bacteria, Neisseria, Escherichia coli, influenza bacillus, Flavobacterium, Pseudomonas aeruginosa, Pseudomonas alcaligenes, Pseudomonas putrefaciens, Burkholderia cepacia, Salmonella typhi bacteria, Pseudomonas aeruginosa, Klebsiella and most Enterobacteriaceae including Citrobacter, cephalothin-resistant Enterobacter, Serratia, Vibrio, cloacae, Acinetobacter, Proteus Bacillus has a high antibacterial activity, and its effect is stronger than that of ampicillin. A variety of anaerobic bacteria (including Ba...

AI Technical Summary

Problems solved by technology

The compound preparation (8:1) or (4:1) composed of piperacillin sodium and tazobactam sodium, in order to increase the solubility, usually put tazobactam sodium or piperacillin sodium and tazobactam sodium together After freeze-drying, crush and repackage, especially when piperacillin sodium and tazobactam sodium are freeze-dried together, the amount of solvent water used is particularly large, which increases energy consumption a lot, increases the process, and the production and processing time is longer than the direct aseptic The powder packaging has increased hundreds of times, but the effect is still unsatisfactory

Because the β-lactam ring is easy to hydrolyze, the β-lactam compound is easy to degrade in the solution state, and the related substances will increase after being placed for a long time, which brings great hidden dangers to the safety of medication