Desonide cyclodextrin clathrate compound and method for preparing the same

A cyclodextrin inclusion compound and cyclodextrin technology, which is applied in the field of cyclodextrin inclusion compound of desonide, can solve the problems of decreased main drug content, easy decomposition, and affecting product stability, so as to achieve formulation stability Improved effect
CN101134108BActive Publication Date: 2010-05-12CHONGQING HUAPONT PHARMA
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
CHONGQING HUAPONT PHARMA
Publication Date
2010-05-12

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Abstract

The present invention relates to cyclodextrin inclusion compound of desonide and its preparation process. The cyclodextrin inclusion compound of desonide has molecule ratio between desonide and cyclodextrin of 0.1-2. It is prepared through adding the alcohol solution of desonide into the water solution of cyclodextrin to include. Compared with common desonide preparation, the cyclodextrin includeddesonide preparation has obviously raised stability.
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Description

Technical field:

[0001] The invention relates to a cyclodextrin inclusion compound of desonide. The invention also relates to the preparation method of the desonide inclusion compound and its preparation. Background technique:

[0002] Desonide is a glucocorticoid drug whose chemical name is 11β, 21-dihydroxy-16α, 17-[(1-methylethylene)-dioxo]pregna-1,4-di ene-3,20-dione.

[0003] Desonide topical can treat a variety of skin diseases. Such as contact dermatitis, eczema and other allergic skin diseases; psoriasis, pityriasis rosea, lichen planus and other erythematous and scaly skin diseases; skin diseases caused by physical factors; pruritic skin diseases; skin vasculitis, etc.

[0004] However, desonide is easy to decompose, especially under the conditions of aqueous solution and light. The main drug content of external preparations containing desonide decreases rapidly during the shelf life, which affects the stability of the product. Therefore, changing the physical ...

Claims

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