Flavonoid compounds and uses thereof

Abstract

Novel flavonoid compounds having anti-oxidant activity are described. The compounds and compositions have been shown to exhibit anti-oxidant properties and are particularly useful in the treatment of ischemia and reperfusion injuries. The invention also describes a method to chemically synthesize such flavonoid compounds and test their efficacy. Such compounds and corresponding pharmaceutically acceptable derivatives and / or salts have uses in the areas of pharmaceuticals, nutraceutical, and veterinary applications.

Description

[0001] Cross References to Related Applications [0002] This application claims priority to Australian Provisional Patent Application No. 2005901214, filed 11 March 2005, the contents of which are incorporated herein by reference. technical field [0003] The present invention relates to novel compounds, compositions containing these compounds, methods for their synthesis, and uses of these compounds. In particular, the present invention relates to flavonoid compounds, methods of synthesizing the flavonoid compounds, compositions containing the flavonoid compounds, and methods of their use. Background technique [0004] Rapid reperfusion of ischemic tissue is critical to restore normal function. However, this restoration of blood flow may cause progressive destruction of reversibly damaged cells, thus leading to tissue dysfunction and infarction. This "reperfusion injury" has a multifactorial etiology and appears to be strongly associated with an inflammatory response; as...

AI Technical Summary

Problems solved by technology

[0017] However, the pharmacokinetics of many flavonoids severely limit their therapeutic use

Synthetic flavonoids tend to be highly fat-soluble molecules and thus tend to have poor water solubility, making them difficult to administer as therapeutics

These characteristics limit their use in treatments requiring acute parenteral administration, such as vasodilation therapy

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