Upkeep liquid as well as preservative fluid for plastocyte

Abstract

The invention provides a preservation liquid for preserving concentrated platelets, which is formed by mixing maintenance medium and plasma, wherein, the plasma accounts for 20 to 30 percent of the total volume; the maintenance medium is the water solution with the pH of 7.2 to 7.3, which contains: 3 to 5 percent glucose, 2 to 4 percent sodium acetate, 2 to 4 percent sodium citrate, 4 to 5 percent sodium dihydrogen phosphate, 3 to 5 percent sodium chloride, 0.3 to 0.5 percent potassium chloride and 0.2 to 0.4 percent magnesium chloride. By adopting the platelet preservation liquid provided by the invention, the preservation time of platelets at 22 DEG C can be prolonged, the recovery rate and activity of platelets after preservation can be improved, the incidence of the adverse actions during blood transfusion process can be reduced, therefore, the invention can ease the insufficient supply of plasma and has good clinical application prospect.

Description

Technical field: [0001] The invention relates to the field of blood preservation, in particular to a platelet preservation solution which can mostly replace blood plasma to preserve concentrated platelets. Background technique: [0002] With the continuous advancement of medical technology in our country, the annual supply of platelets is in short supply, and the demand is increasing year by year. The annual growth rate of platelet demand in Beijing is 10%. There are more than 50 hospitals above Grade 3 in Beijing, and there are about hundreds of related departments involved in platelet transfusion. At present, plasma is generally used to store platelets at room temperature clinically, and the storage period at 22°C is 5 days. Due to the loss of function and the possibility of bacterial infection, platelets are often discarded, resulting in waste; on the other hand, the recovery rate and activity of platelets after plasma preservation are reduced, which will also cause waste...

AI Technical Summary

Problems solved by technology

However, these maintenance solutions cannot provide more sufficient energy for platelet metabolism, resulting in unsatisfactory activity of platelets, and the recovery rate is still reduced

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