Application of Salvia przewalskii Maxim extract in the preparation of medicament for curing nephritis of renal glomerulus

A technology of Ganxi sage, glomerulonephritis, applied in the field of medicine

Active Publication Date: 2008-05-21
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] At present, there is no literature report that Clary sage has the effect of treating glomerulonephritis

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] The preparation of embodiment 1 Clary sage extract

[0018] After 100kg of dry medicinal materials of Sage sage root are crushed, pass through a 10-mesh sieve, put into an extraction tank, soak in 200L of 40% ethanol at room temperature for 24 hours, extract by percolation with 1500L of 40% ethanol at room temperature for 3 times, combine and soak Liquid and extract, concentrated to 100L, filtered after centrifugation, discarded precipitate, the filtrate was subjected to polystyrene porous adsorption macroporous resin adsorption, the macroporous resin loading capacity in the column was 200L, leached with 1000L distilled water to remove impurities, and then Then eluted with 1500L of 40% aqueous ethanol, the combined eluent was concentrated until it had no alcohol smell, and further dried to obtain 1.8 kg of tan powdery Sage Sage extract. Calculated according to the dosage of crude drug, the yield of Sage ganxie extract is 1.8%.

Embodiment 2

[0019] Therapeutic effect of embodiment 2 Ganxi sage extract on glomerulonephritis rats

[0020] In this experiment, rats were given different doses of Sage ganxie extract by intragastric administration to observe its improvement and therapeutic effect on glomerulonephritis.

[0021] 1 Materials and methods

[0022] 1.1 Test drugs

[0023] The Clary Sage ganxi extract prepared according to the method of Example 1

[0024] Physical and chemical properties: brown powder

[0025] Storage conditions: airtight storage at room temperature

[0026] Mass: 500g

[0027] Packaging: plastic bottle

[0028] Preparation method: Grind and suspend 0.8% sodium carboxymethylcellulose evenly, and prepare the desired concentration

[0029] 1.2 Experimental materials

[0030] BSA (produced by Sangon Bioengineering (Shanghai) Co., Ltd., 25g / bottle, batch number 0409A09)

[0031] Freund's adjuvant (manufactured by Sigma, 10×10ml, batch number 122K8927)

[0032] Tripterygium glycosides tabl...

experiment example 3

[0073] Experimental Example 3 Effect of Sage Sage Extract on Blood Viscosity of Normal Rats

[0074] In this experiment, rats were given different doses of Sage ganxie extract by intragastric administration, and its effect on hemorheology of normal rats was observed.

[0075] 1 Materials and methods

[0076] 1.1 Test drugs

[0077] The Clary Sage ganxi extract prepared according to the method of Example 1

[0078] Physical and chemical properties: brown powder

[0079] Storage conditions: airtight storage at room temperature

[0080] Mass: 500g

[0081] Packaging: plastic bottle

[0082] Preparation method: Grind and suspend 0.8% sodium carboxymethylcellulose evenly, and prepare the desired concentration

[0083] 1.2 Experimental materials

[0084] Tripterygium glycosides tablets (produced by Shanghai Fudan Fuhua Pharmaceutical Co., Ltd., 100mg×100 tablets, batch number 040901, valid until August 2007, made into a 1.5mg / ml solution with 0.8% sodium carboxymethylcellulos...

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PUM

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Abstract

The invention relates to the technical field of medicine. The clinical manifestations of glomerulonephritis are proteinuria, hematuria, edema, hypertension, etc. Among them, chronic glomerulonephritis has a long course of disease, often has different degrees of renal function damage, and has recurrent attacks, and the prognosis is poor. The purpose of the present invention is to provide the application of Clary sage extract in the preparation of medicine for treating glomerulonephritis. The invention provides an extract of sage ganxie obtained by drying and pulverizing medicinal materials of the roots of sage ganxie, soaking them in water-containing lower alcohol, extracting by percolation or heating, and concentrating and drying the extract. The above-mentioned Clary Sage extract has been confirmed by animal experiments to significantly reduce the urinary protein content of serum sickness glomerulonephritis model rats, and can significantly reduce the swelling of the glomerulus, and also has the ability to reduce blood viscosity and diuresis. therapeutic effect. The invention not only provides a new application for the ganxi sage, but also provides a new treatment drug for the majority of nephritis patients.

Description

technical field [0001] The invention relates to the technical field of medicines, in particular to the application of Clary sage extract in the preparation of medicines for treating glomerulonephritis. Background technique [0002] Glomerulonephritis is a glomerular disease caused by a variety of etiologies. It can be clinically manifested as proteinuria, hematuria, edema, hypertension, etc. It can be divided into acute glomerulonephritis and chronic glomerulonephritis. Acute glomerulonephritis has an acute onset and a short course of disease, with hematuria, proteinuria, oliguria, even azotemia, edema, and high blood pressure as the main symptoms. After active treatment, the prognosis is good; chronic glomerulonephritis has a long course of disease, Most have different degrees of renal impairment, and recurrent attacks, the prognosis is poor, if not actively treated, most of them will eventually develop into chronic renal failure, that is, uremia. [0003] Glomerulonephrit...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/537A61P13/12A61K125/00
Inventor 孙连娜陈万生杨阳张凤来威曹永兵姜远英
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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