Dectancyl partial film forming gel composition and uses thereof

Abstract

The invention discloses a dexamethasone acetate local film-forming gel compound, comprising the following weight-percentage components: 0.5 to 7 percent of hydroxyalkyl fibrin, 1 to 10 percent of esterifying agent, 0.5 to 5 percent of crosslinking agent, 75 to 90 percent of menstruum and 0.01 to 3 percent of dexamethasone acetate; wherein, the crosslinking agent is a saturated fat polyol or alkydwhich has the chemical general equation of CnH2n+2-m-l (OH) m (COOH) l, and n, m and l are whole numbers and n is more than or equal to m which is more than or equal to 2, and l is more than or equalto 0, and m plus 1 is from 4 to 8 and n plus 1 is from 4 to 8. The dexamethasone acetate local film-forming gel compound of the invention is used for treating ulcer of mouth or skin. When the invention is spread onto an ulcer surface, a smooth, tough, wear-resistant and durable waterproof protection film can be formed. The dexamethasone acetate can be released to the ulcer surface through the film to promote the cure of ulcer. The formed film can be preserved for about 5 hours on the surface of oral mucosa, so as to shield outer stimulants to the ulcer and the existence of film cannot be feltin the oral cavity. And the film can be preserved for more than 7 hours on the skin surface and the adherence of the film is durable.

Description

technical field [0001] The invention relates to a local film-forming gel composition of dexamethasone acetate and its application in treating diseases such as oral cavity, skin ulcer or skin eczema. Background technique [0002] Oral mucosa / skin ulcers, or skin eczema are common diseases that people often encounter in daily life. The topical pharmaceutical preparations clinically used to treat oral mucosa / skin ulcers or skin eczema are usually pastes, gargles, creams, ointments, gels, etc., when these preparations are used for local treatment on the oral mucosa or skin At the same time, due to the normal activities of the treatment site and surrounding tissues, such as friction, secretion and washing of body fluids and saliva, these agents will dissolve and / or erode, shift, and fall off. The residence time generally does not exceed 15 minutes, and does not exceed 30 minutes on the skin surface, which significantly reduces the curative effect. [0003] Some topical film-for...

AI Technical Summary

Problems solved by technology

However, we have found that the local film-forming gel composition made of monoglyceryl laurate as a cross-linking agent, although the flexibility of the film is enhanced, the time of adhesion to body tissues or mucous membranes is relatively short, as in The film formed on the oral mucosa is easily eroded / dissolved by body fluids or saliva, causing the film to rupture prematurely, fall off, and even disappear, and its effective residence time on the oral mucosa is only 3 to 4 hours

[0007] Therefore, as adopting the technology of above-mentioned existing film-forming gel composition to prepare dexamethasone acetate local film-forming gel, the retention time of the medicament and the affected part will be shorter, and the therapeutic effect is lower, so there is no dexamethasone acetate yet. Topical film-forming gel commercially launched

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